High selectivity and exquisite control over the outcome of reactions entice chemists to use
biocatalysts in organic synthesis. However, many useful reactions are not accessible …

Direct C–H bond functionalization catalyzed by non-precious transition metals is an
attractive strategy in synthetic chemistry. Compared with the precious metals rhodium …

Artificial metalloenzymes (ArMs) formed by incorporating synthetic metal catalysts into
protein scaffolds have the potential to impart to chemical reactions selectivity that would be …

One of the greatest challenges in protein design is creating new enzymes, something
evolution does all the time, starting from existing ones. Borrowing from nature's evolutionary …

Enzymes exercise impeccable control over chemoselectivity, site selectivity and
stereoselectivity in reactions they mediate, such that we have witnessed a surge in the …

Despite the astonishing breadth of enzymes in nature, no enzymes are known for many of
the valuable catalytic transformations discovered by chemists. Recent work in enzyme …

Myoglobin-catalyzed intermolecular carbene N–H insertion with arylamine substrates -
Chemical Communications (RSC Publishing) DOI:10.1039/C4CC08753D Royal Society of …

Artificial metalloenzymes have received increasing attention over the last decade as a
possible solution to unaddressed challenges in synthetic organic chemistry. Whereas …

Myoglobin reconstituted with iron porphycene catalyzes the cyclopropanation of styrene with
ethyl diazoacetate. Compared to native myoglobin, the reconstituted protein significantly …

I describe how we direct the evolution of non-natural enzyme activities, using chemical
intuition and information on structure and mechanism to guide us to the most promising …