Molecular mechanisms responsible for therapeutic potential of mesenchymal stem cell-derived secretome
CR Harrell, C Fellabaum, N Jovicic, V Djonov… - Cells, 2019 - mdpi.com
Mesenchymal stem cell (MSC)-sourced secretome, defined as the set of MSC-derived
bioactive factors (soluble proteins, nucleic acids, lipids and extracellular vesicles), showed …
bioactive factors (soluble proteins, nucleic acids, lipids and extracellular vesicles), showed …
The healing power of neutrophils
M Phillipson, P Kubes - Trends in immunology, 2019 - cell.com
Neutrophils promptly accumulate in large numbers at sites of tissue injury. Injuries to the skin
or mucosae disrupt barriers against the external environment, and the bactericidal actions of …
or mucosae disrupt barriers against the external environment, and the bactericidal actions of …
MSC exosome as a cell-free MSC therapy for cartilage regeneration: implications for osteoarthritis treatment
Mesenchymal stem cell (MSC) therapies have demonstrated efficacy in cartilage repair in
animal and clinical studies. The efficacy of MSC-based therapies which was previously …
animal and clinical studies. The efficacy of MSC-based therapies which was previously …
Inflammation and the intestinal barrier: leukocyte–epithelial cell interactions, cell junction remodeling, and mucosal repair
The intestinal tract is lined by a single layer of columnar epithelial cells that forms a dynamic,
permeable barrier allowing for selective absorption of nutrients, while restricting access to …
permeable barrier allowing for selective absorption of nutrients, while restricting access to …
Mesenchymal stem cell exosomes enhance periodontal ligament cell functions and promote periodontal regeneration
Mesenchymal stem cells (MSCs) are potential therapeutics for the treatment of periodontal
defects. It is increasingly accepted that MSCs mediate tissue repair through secretion of …
defects. It is increasingly accepted that MSCs mediate tissue repair through secretion of …
Mesenchymal stem cell exosomes
MSCs are an extensively used cell type in clinical trials today. The initial rationale for their
clinical testing was based on their differentiation potential. However, the lack of correlation …
clinical testing was based on their differentiation potential. However, the lack of correlation …
Genomics and evolution of protein phosphatases
Protein phosphatases are the essential opposite to protein kinases; together, these enzymes
regulate all protein phosphorylation and most cellular processes. To better understand the …
regulate all protein phosphorylation and most cellular processes. To better understand the …
CD73 on cancer-associated fibroblasts enhanced by the A2B-mediated feedforward circuit enforces an immune checkpoint
M Yu, G Guo, L Huang, L Deng, CS Chang… - Nature …, 2020 - nature.com
Abstract CD73, an ecto-5′-nucleotidase (NT5E), serves as an immune checkpoint by
generating adenosine (ADO), which suppresses immune activation through the A2A …
generating adenosine (ADO), which suppresses immune activation through the A2A …
The multifaceted roles neutrophils play in the tumor microenvironment
Neutrophils are myeloid cells that constitute 50–70% of all white blood cells in the human
circulation. Traditionally, neutrophils are viewed as the first line of defense against infections …
circulation. Traditionally, neutrophils are viewed as the first line of defense against infections …
Cellular function and molecular structure of ecto-nucleotidases
Ecto-nucleotidases play a pivotal role in purinergic signal transmission. They hydrolyze
extracellular nucleotides and thus can control their availability at purinergic P2 receptors …
extracellular nucleotides and thus can control their availability at purinergic P2 receptors …