Heart disease remains the leading cause of death and disability in the Western world.
Current therapies aim at treating the symptoms rather than the subcellular mechanisms …

Mitochondria play an important role in cell death and cardioprotection. During ischemia,
when ATP is progressively depleted, ion pumps cannot function resulting in a rise in calcium …

Acute heart failure (HF) and in particular, cardiogenic shock are associated with high
morbidity and mortality. A therapeutic dilemma is that the use of positive inotropic agents …

Ca2+-dependent signaling is highly regulated in cardiomyocytes and determines the force
of cardiac muscle contraction. Ca2+ cycling refers to the release and reuptake of …

Abstract Intracellular calcium (Ca 2+) is a critical coordinator of various aspects of cellular
physiology. It is increasingly apparent that changes in cellular Ca 2+ dynamics contribute to …

The sarcoendoplasmic reticulum (SR) calcium transport ATPase (SERCA) is a pump that
transports calcium ions from the cytoplasm into the SR. It is present in both animal and plant …

Adult mammalian hearts respond to injury with scar formation and not with cardiomyocyte
proliferation, the cellular basis of regeneration. Although cardiogenic progenitor cells may …

The endoplasmic reticulum (ER) is a morphologically and functionally diverse organelle
capable of integrating multiple extracellular and internal signals and generating adaptive …

Gene therapy is a promising modality for the treatment of inherited and acquired
cardiovascular diseases. The identification of the molecular pathways involved in the …

Objectives: The aim of this study was to examine the effects of sarcoplasmic reticulum Ca2+
ATPase (SERCA2a) gene transfer in a swine heart failure (HF) model. Background …