Abstract limma is an R/Bioconductor software package that provides an integrated solution
for analysing data from gene expression experiments. It contains rich features for handling …

Neurodegenerative disorders such as Alzheimer's disease (AD), Lewy body diseases (LBD),
and the amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD) spectrum are …

Identifying differentially abundant microbes is a common goal of microbiome studies.
Multiple methods are used interchangeably for this purpose in the literature. Yet, there are …

Traditionally viewed as poorly plastic, neutrophils are now recognized as functionally
diverse; however, the extent and determinants of neutrophil heterogeneity in humans remain …

Aryl hydrocarbon receptor (AHR) activation by tryptophan (Trp) catabolites enhances tumor
malignancy and suppresses anti-tumor immunity. The context specificity of AHR target …

An improved understanding of the anti-tumor CD8+ T cell response after checkpoint
blockade would enable more informed and effective therapeutic strategies. Here we …

In recent years, RNA sequencing (RNA-seq) has become a very widely used technology for
profiling gene expression. One of the most common aims of RNA-seq profiling is to identify …

High-grade serous ovarian cancers have low survival rates because of their late
presentation with extensive peritoneal metastases and frequent chemoresistance, and …

The tumor microenvironment (TME) contains a rich source of nutrients that sustains cell
growth and facilitate tumor development. Glucose and glutamine in the TME are essential for …

Gene expression by RNA polymerase II (RNAPII) is tightly controlled by cyclin-dependent
kinases (CDKs) at discrete checkpoints during the transcription cycle. The pausing …