During aging, the cellular milieu of the brain exhibits tell-tale signs of compromised
bioenergetics, impaired adaptive neuroplasticity and resilience, aberrant neuronal network …

An important concept in neurobiology is “neurons that fire together, wire together” which
means that the formation and maintenance of synapses is promoted by activation of those …

Epidemiological, neuropathological, and functional neuroimaging evidence implicates
global and regional disruptions in brain metabolism and energetics in the pathogenesis of …

Alzheimer's disease (AD) involves progressive accumulation of amyloid β-peptide (Aβ) and
neurofibrillary pathologies, and glucose hypometabolism in brain regions critical for …

Epidemiological studies show that patients with type 2 diabetes (T2DM) and individuals with
a diabetes-independent elevation in blood glucose have an increased risk for developing …

Basal forebrain cholinergic neurons (BFCNs) are believed to be one of the first cell types to
be affected in all forms of AD, and their dysfunction is clinically correlated with impaired short …

Considerable information is currently available from neuroimaging, pathological, and
population-based prospective studies showing that vascular risk factors are independently …

The pathology-based classification of Alzheimer's disease (AD) and other
neurodegenerative diseases is a work in progress that is important for both clinicians and …

More than two dozen clinical syndromes known as amyloid diseases are characterized by
the buildup of extended insoluble fibrillar deposits in tissues. These amorphous Congo red …

Impaired brain energy metabolism and oxidative stress are implicated in cognitive decline
and the pathologic accumulations of amyloid β-peptide (Aβ) and hyperphosphorylated tau in …