The pleckstrin homology [PH] domain is a structural fold found in more than 250 proteins
making it the 11th most common domain in the human proteome. 25% of family members …

Since the first clinical report in 2013, inhibitors of the intracellular kinase BTK (BTKi) have
profoundly altered the treatment paradigm of B cell malignancies, replacing chemotherapy …

Bruton tyrosine kinase (BTK) inhibitor therapy induces peripheral blood lymphocytosis in
chronic lymphocytic leukemia (CLL), which lasts for several months. It remains unclear …

Chronic lymphocytic leukemia (CLL) cells extensively interact with and depend on their
surrounding tumor microenvironment (TME). The TME encompasses a heterogeneous array …

The Bruton's tyrosine kinase (BTK) inhibitor ibrutinib represents an effective strategy for
treatment of chronic lymphocytic leukemia (CLL), nevertheless about 30% of patients …

The t (14; 19)(q32; q13) often juxtaposes BCL3 with immunoglobulin heavy chain (IGH)
resulting in overexpression of the gene. In contrast to other oncogenic translocations, BCL3 …

The Bruton tyrosine kinase (BTK) inhibitor ibrutinib is widely used for treatment of patients
with relapsed/refractory or treatment-naïve chronic lymphocytic leukemia (CLL). A prominent …

Forkhead box (FOX) class O (FOXO) proteins are a dynamic family of transcription factors
composed of four family members: FOXO1, FOXO3, FOXO4 and FOXO6. As context …

Peptides that form transmembrane barrel-stave pores are potential alternative therapeutics
for bacterial infections and cancer. However, their optimization for clinical translation is …

Simple Summary GRB2-associated binder 1 (GAB1) is a docking protein pivotal in linking
multiple stimuli to various intracellular signaling pathways. Embryonic development is …