The release and absorption profile of an oral medication is influenced by the
physicochemical properties of the drug and its formulation, as well as by the anatomy and …

Glucuronidation and sulfation are the most typical phase II metabolic reactions of drugs. The
resulting glucuronide and sulfate conjugates are generally considered inactive and safe …

The absorption, distribution and excretion of drugs are largely determined by their
transporters (DTs), the variability of which has thus attracted considerable attention. There …

Drug transporters can govern the absorption, distribution, metabolism, and excretion of
substrate drugs and endogenous substances. Investigations to examine their potential …

Membrane transport proteins are involved in the absorption, disposition, efficacy, and/or
toxicity of many drugs. Numerous mechanisms (eg, nuclear receptors, epigenetic gene …

Drug transporters play an essential role in disposition and effects of multiple drugs. Plasma
concentrations of the victim drug can be modified by drug–drug interactions occurring in …

The role of membrane transporters on pharmacokinetics (PKs), drug–drug interactions
(DDIs), pharmacodynamics (PDs), and toxicity of drugs has been broadly recognized …

Inflammation is a possible cause of variability in drug response and toxicity due to altered
regulation in drug‐metabolizing enzymes and transporters (DMETs) in humans. Here, we …

Human renal membrane transporters play key roles in the disposition of renally cleared
drugs and endogenous substrates, but their ontogeny is largely unknown. Using 184 human …

Gegen-Qinlian decoction (GQD) is a classic traditional Chinese medicine (TCM) formula. It is
composed of four TCMs, including Puerariae Lobatae Radix, Scutellariae Radix, Coptidis …