Molecular biology of osteosarcoma
AM Czarnecka, K Synoradzki, W Firlej, E Bartnik… - Cancers, 2020 - mdpi.com
Osteosarcoma (OS) is the most frequent primary bone cancer in children and adolescents
and the third most frequent in adults. Many inherited germline mutations are responsible for …
and the third most frequent in adults. Many inherited germline mutations are responsible for …
Exosome-mediated miR-144-3p promotes ferroptosis to inhibit osteosarcoma proliferation, migration, and invasion through regulating ZEB1
M Jiang, Y Jike, K Liu, F Gan, K Zhang, M Xie, J Zhang… - Molecular Cancer, 2023 - Springer
Background Osteosarcoma (OS) is the most prevalent orthopedic malignancy with a dismal
prognosis. The high iron absorption rate in OS cells of patients suggests that ferroptosis may …
prognosis. The high iron absorption rate in OS cells of patients suggests that ferroptosis may …
Exosomal PD-L1 and N-cadherin predict pulmonary metastasis progression for osteosarcoma patients
J Wang, H Zhang, X Sun, X Wang, T Ren… - Journal of …, 2020 - Springer
Background Recent studies indicated that exosomal programmed death-ligand 1 (PD-L1)
derived from cancers could induce immunosuppression and tumor pathogenesis. However …
derived from cancers could induce immunosuppression and tumor pathogenesis. However …
Exosomal communication by metastatic osteosarcoma cells modulates alveolar macrophages to an M2 tumor-promoting phenotype and inhibits tumoricidal functions
K Wolf-Dennen, N Gordon, ES Kleinerman - Oncoimmunology, 2020 - Taylor & Francis
Osteosarcoma metastasizes to the lung, and there is a link between the predominance of
tumor-promoting immunosuppressive M2 macrophages in the metastases and poor patient …
tumor-promoting immunosuppressive M2 macrophages in the metastases and poor patient …
Mitochondrial DNA damage and subsequent activation of Z-DNA binding protein 1 links oxidative stress to inflammation in epithelial cells
This report identifies mitochondrial DNA (mtDNA) as a target and active mediator that links
low-level oxidative stress to inflammatory response in pulmonary epithelial cells. Extrusion …
low-level oxidative stress to inflammatory response in pulmonary epithelial cells. Extrusion …
Carcinogenic epithelial-mesenchymal transition initiated by oral cancer exosomes is inhibited by anti-EGFR antibody cetuximab
T Fujiwara, T Eguchi, C Sogawa, K Ono, J Murakami… - Oral oncology, 2018 - Elsevier
Overexpression and increased signaling from the epidermal growth factor receptor (EGFR)
often changes oral squamous cell carcinoma (OSCC) and thus EGFR is frequently targeted …
often changes oral squamous cell carcinoma (OSCC) and thus EGFR is frequently targeted …
Exosomes in the tumor microenvironment of sarcoma: from biological functions to clinical applications
H Ye, X Hu, Y Wen, C Tu, F Hornicek, Z Duan… - Journal of …, 2022 - Springer
The current diagnosis and treatment of sarcoma continue to show limited timeliness and
efficacy. In order to enable the early detection and management of sarcoma, increasing …
efficacy. In order to enable the early detection and management of sarcoma, increasing …
The roles of exosomal proteins: classification, function, and applications
XX Li, LX Yang, C Wang, H Li, DS Shi… - International Journal of …, 2023 - mdpi.com
Exosome, a subpopulation of extracellular vesicles, plays diverse roles in various biological
processes. As one of the most abundant components of exosomes, exosomal proteins have …
processes. As one of the most abundant components of exosomes, exosomal proteins have …
SERS and MALDI-TOF MS based plasma exosome profiling for rapid detection of osteosarcoma
Osteosarcoma is the most frequent primary bone cancer, particularly among children and
adolescents. The early diagnosis of osteosarcoma is significant for timely clinical treatment …
adolescents. The early diagnosis of osteosarcoma is significant for timely clinical treatment …