Ketamine produces immediate antidepressant effects and has inspired research into next-
generation treatments. Ketamine also has short term dissociative effects, in which …

Controversy about dissociation and the dissociative disorders (DD) has existed since the
beginning of modern psychiatry and psychology. Even among professionals, beliefs about …

Background Electroconvulsive therapy (ECT) and subanesthetic intravenous ketamine are
both currently used for treatment-resistant major depression, but the comparative …

Objective: About one-third of patients with depression fail to achieve remission despite
treatment with multiple antidepressants. This study compared the efficacy and safety of …

Importance Controlled studies have shown short-term efficacy of esketamine for treatment-
resistant depression (TRD), but long-term effects remain to be established. Objective To …

Background About one-third of patients with depression fail to achieve remission despite
treatment with multiple antidepressants and are considered to have treatment-resistant …

Objective: Posttraumatic stress disorder (PTSD) is a chronic and disabling disorder, for
which available pharmacotherapies have limited efficacy. The authors' previous proof-of …

Objective: In addition to N-methyl-d-aspartate receptor antagonism, ketamine produces
opioid system activation. The objective of this study was to determine whether opioid …

Objective: Subanesthetic ketamine doses have been shown to have rapid yet transient
antidepressant effects in patients with treatment-resistant depression, which may be …

BackgroundRecent open-label trials show that psychedelics, such as ayahuasca, hold
promise as fast-onset antidepressants in treatment-resistant depression. MethodsTo test the …