Molecular mechanism of heavy metals (Lead, Chromium, Arsenic, Mercury, Nickel and Cadmium)-induced hepatotoxicity–A review

K Renu, R Chakraborty, H Myakala, R Koti… - Chemosphere, 2021 - Elsevier
Heavy metals pose a serious threat if they go beyond permissible limits in our bodies. Much
heavy metal's viz. Lead, Chromium, Arsenic, Mercury, Nickel, and Cadmium pose a serious …

Rutin ameliorates inflammation and improves metabolic function: A comprehensive analysis of scientific literature

N Muvhulawa, PV Dludla, K Ziqubu… - Pharmacological …, 2022 - Elsevier
Chronic inflammation remains an essential complication in the pathogenesis and
aggravation of metabolic diseases. There is a growing interest in the use of medicinal plants …

Protective effects of microbiome-derived inosine on lipopolysaccharide-induced acute liver damage and inflammation in mice via mediating the TLR4/NF-κB pathway

W Guo, Q Xiang, B Mao, X Tang, S Cui… - Journal of agricultural …, 2021 - ACS Publications
This research assessed the anti-inflammatory and hepatoprotective properties of inosine
and the associated mechanism. Inosine pretreatment significantly reduced the secretion of …

Protective effects of chrysin against oxidative stress and inflammation induced by lead acetate in rat kidneys: a biochemical and histopathological approach

S Kucukler, F Benzer, S Yildirim, C Gur… - … Trace Element Research, 2021 - Springer
In this study, the protective effects of chrysin (CR) on lead acetate (PbAc)-induced renal
toxicity in Sprague-Dawley rats were investigated with biochemical, histopathological, and …

Beneficial effects of Chrysin on Cadmium‐induced nephrotoxicity in rats: Modulating the levels of Nrf2/HO‐1, RAGE/NLRP3, and Caspase-3/Bax/Bcl-2 signaling …

H Şimşek, N Akaras, C Gür, S Küçükler, FM Kandemir - Gene, 2023 - Elsevier
Cadmium (Cd) is a toxic heavy metal that targets the kidney directly in the body. Chrysin
(CHR) is a natural flavonoid with many properties such as antioxidant, anti-inflammatory and …

Protective effects of morin against acrylamide-induced hepatotoxicity and nephrotoxicity: A multi-biomarker approach

FM Kandemir, S Yıldırım, S Kucukler… - Food and chemical …, 2020 - Elsevier
Acrylamide (ACR) is a heat-induced carcinogen substance that is found in some foods due
to cooking or other thermal processes. The aim of present study was to assess the probable …

Hesperidin protects against the chlorpyrifos‐induced chronic hepato‐renal toxicity in rats associated with oxidative stress, inflammation, apoptosis, autophagy, and up …

S Küçükler, S Çomaklı, S Özdemir… - Environmental …, 2021 - Wiley Online Library
In this study, we investigated the effects of hesperidin (HSP) on oxidants/antioxidants status,
inflammation, apoptotic, and autophagic activity in hepato‐renal toxicity induced by chronic …

Evaluation of protective effects of quercetin against cypermethrin‐induced lung toxicity in rats via oxidative stress, inflammation, apoptosis, autophagy, and …

M Ileriturk, O Kandemir… - Environmental …, 2022 - Wiley Online Library
Cypermethrin (CYP), a type II synthetic pyrethroid, is the most widely used insecticide
worldwide. Inhalation of it may cause side effects. This study is aimed to examine potential …

Protective effect of chrysin on cyclophosphamide-induced hepatotoxicity and nephrotoxicity via the inhibition of oxidative stress, inflammation, and apoptosis

Y Temel, S Kucukler, S Yıldırım, C Caglayan… - Naunyn-Schmiedeberg's …, 2020 - Springer
Cyclophosphamide (CYP) is a chemotherapeutic agent used in the treatment of autoimmune
disorders and malignant diseases. However, its usage is restricted due to its severe side …

Rutin protects rat liver and kidney from sodium valproate-induce damage by attenuating oxidative stress, ER stress, inflammation, apoptosis and autophagy

FM Kandemir, M Ileriturk, C Gur - Molecular biology reports, 2022 - Springer
Background The present study investigated the effects of rutin (RUT), which has various
biological and pharmacological properties, on liver and kidney damage caused by histone …