The formation of new blood vessels is a crucial step in the development of any new tissue
both during embryogenesis and in vitro models as without sufficient perfusion the tissue will …

Hereditary hemorrhagic telangiectasia (HHT) management is evolving because of the
emergence and development of antiangiogenic therapies to eliminate bleeding …

Background Hereditary hemorrhagic telangiectasia (HHT) is characterized by extensive
telangiectasias and arteriovenous malformations. The primary clinical manifestation is …

Correct organization of the vascular tree requires the balanced activities of several signaling
pathways that regulate tubulogenesis and vascular branching, elongation, and pruning …

Vascular anomalies represent a diverse group of disorders classified broadly as
malformations or tumors and include the second most common hereditary bleeding disorder …

Pericytes are mesenchymal-derived mural cells localized within the basement membrane of
pulmonary and systemic capillaries. Besides structural support, pericytes control vascular …

Radiation-induced brain injury (RIBI) is a debilitating sequela after radiotherapy to treat
head and neck cancer, and 20 to 30% of patients with RIBI fail to respond to or have …

Background Hereditary hemorrhagic telangiectasia (HHT) is a multisystemic inherited
vascular dysplasia that leads to nosebleeds and visceral arteriovenous malformations …

Hereditary hemorrhagic telangiectasia (HHT) is a rare angiogenic disorder causing chronic
gastrointestinal bleeding, epistaxis, and severe anemia. Pazopanib is an oral multi-kinase …

Gastrointestinal angiodysplasia (GIA) is a common, acquired, vascular abnormality of the
digestive tract, and a frequent cause of bleeding. Refractory GIA criteria usually include …