RNA interference in cancer
AL Gartel, ES Kandel - Biomolecular engineering, 2006 - Elsevier
In the recent years, RNA interference (RNAi) has emerged as a major regulatory mechanism
in eukaryotic gene expression. The realization that changes in the levels of microRNAs are …
in eukaryotic gene expression. The realization that changes in the levels of microRNAs are …
Gene manipulation through the use of small interfering RNA (siRNA): from in vitro to in vivo applications
The conventional approach to investigate genotype–phenotype relationships has been the
generation of gene targeted murine strains. However, the emergence of RNAi technologies …
generation of gene targeted murine strains. However, the emergence of RNAi technologies …
Method for making a 21 nucleotide double stranded RNA chemically linked at one end
R Kreutzer, S Limmer - US Patent 8,168,776, 2012 - Google Patents
US8168776B2 - Method for making a 21 nucleotide double stranded RNA chemically linked
at one end - Google Patents US8168776B2 - Method for making a 21 nucleotide double …
at one end - Google Patents US8168776B2 - Method for making a 21 nucleotide double …
Method and medicament for inhibiting the expression of a given gene
R Kreutzer, S Limmer - US Patent 8,101,584, 2012 - Google Patents
US8101584B2 - Method and medicament for inhibiting the expression of a given gene -
Google Patents US8101584B2 - Method and medicament for inhibiting the expression of a …
Google Patents US8101584B2 - Method and medicament for inhibiting the expression of a …
Selection and validation of optimal siRNA target sites for RNAi-mediated gene silencing
Q Luo, Q Kang, WX Song, HH Luu, X Luo, N An, J Luo… - Gene, 2007 - Elsevier
RNA interference (RNAi)-mediated gene silencing has become a valuable tool for functional
studies, reverse genomics, and drug discoveries. One major challenge of using RNAi is to …
studies, reverse genomics, and drug discoveries. One major challenge of using RNAi is to …
Genome-wide Antisense Oligonucleotide and RNAi
T Chen, J Li, TM Chen, L Xi, S Zhang - US Patent App. 14/141,404, 2014 - Google Patents
US20140315755A1 - Genome-wide Antisense Oligonucleotide and RNAi - Google Patents
US20140315755A1 - Genome-wide Antisense Oligonucleotide and RNAi - Google Patents …
US20140315755A1 - Genome-wide Antisense Oligonucleotide and RNAi - Google Patents …
RNA interference mediating small RNA molecules
T Tuschl, SM Elbashir, W Lendeckel - US Patent 8,372,968, 2013 - Google Patents
Double-stranded RNA (dsRNA) induces sequence-specific post-transcriptional gene
silencing in many organisms by a process known as RNA interference (RNAi). Using a …
silencing in many organisms by a process known as RNA interference (RNAi). Using a …
Circular siRNAs for reducing off-target effects and enhancing long-term gene silencing in cells and mice
L Zhang, D Liang, C Chen, Y Wang, G Amu… - … Therapy-Nucleic Acids, 2018 - cell.com
Circular non-coding RNAs are found to play important roles in biology but are still relatively
unexplored as a structural motif for chemically regulating gene function. Here, we …
unexplored as a structural motif for chemically regulating gene function. Here, we …
RNA interference mediating small RNA molecules
T Tuschl, SM Elbashir, W Lendeckel - US Patent 8,362,231, 2013 - Google Patents
Double-stranded RNA (dsRNA) induces sequence-specific post-transcriptional gene
silencing in many organisms by a process known as RNA interference (RNAi). Using a …
silencing in many organisms by a process known as RNA interference (RNAi). Using a …
RNA sequence-specific mediators of RNA interference
The present invention relates to a Drosophila in vitro system which was used to demonstrate
that dsRNA is processed to RNA segments 21-23 nucleotides (nt) in length. Furthermore …
that dsRNA is processed to RNA segments 21-23 nucleotides (nt) in length. Furthermore …