Targeting arachidonic acid pathway by natural products for cancer prevention and therapy

NS Yarla, A Bishayee, G Sethi, P Reddanna… - Seminars in cancer …, 2016 - Elsevier
Arachidonic acid (AA) pathway, a metabolic process, plays a key role in carcinogenesis.
Hence, AA pathway metabolic enzymes phospholipase A 2 s (PLA 2 s), cyclooxygenases …

Oncopreventive and oncotherapeutic potential of licorice triterpenoid compound glycyrrhizin and its derivatives: Molecular insights

R Jain, MA Hussein, S Pierce, C Martens… - Pharmacological …, 2022 - Elsevier
Licorice (Glycyrrhiza glabra) is a well-known natural herb used to treat different ailments
since ancient times. Glycyrrhizin (GL), which is the primary triterpenoid compound of licorice …

[PDF][PDF] Prostaglandin pathways: opportunities for cancer prevention and therapy

Q Wang, RJ Morris, AM Bode, T Zhang - Cancer research, 2022 - AACR
Because of profound effects observed in carcinogenesis, prostaglandins (PGs),
prostaglandin-endoperoxide synthases, and PG receptors are implicated in cancer …

Human cytochrome P450 enzymes

FP Guengerich - Cytochrome P450: structure, mechanism, and …, 2015 - Springer
Abstract The cytochrome P450 (P450) enzymes first attracted interest because of their
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …

Mechanisms and biomarkers of cancer-associated thrombosis

AS Kim, AA Khorana, KR McCrae - Translational Research, 2020 - Elsevier
Cancer-associated thrombosis is a leading cause of non-cancer death in cancer patients
and is comprised of both arterial and venous thromboembolism (VTE). There are multiple …

Transient and stable vector transfection: Pitfalls, off-target effects, artifacts

AA Stepanenko, HH Heng - Mutation Research/Reviews in Mutation …, 2017 - Elsevier
Transient and stable vector transfections have played important roles in illustrating the
function of specific genes/proteins. The general assumption is that such a platform could …

Impacts of cancer on platelet production, activation and education and mechanisms of cancer-associated thrombosis

L Plantureux, D Mège, L Crescence, F Dignat-George… - Cancers, 2018 - mdpi.com
Platelets are small anucleate cells that are traditionally described as the major effectors of
hemostasis and thrombosis. However, increasing evidence indicates that platelets play …

The platelet–cancer loop

HA Goubran, T Burnouf, M Radosevic… - European journal of …, 2013 - Elsevier
The relationship between cancer and thrombosis has been established since 1865 when
Armand Trousseau described superficial thrombophlebitis as forewarning sign of occult …

Platelet–cancer interactions

HA Goubran, J Stakiw, M Radosevic… - … in thrombosis and …, 2014 - thieme-connect.com
Platelets play a crucial role in the pathophysiological processes of hemostasis and
thrombosis. Increasing evidence indicates that they fulfill much broader roles in balancing …

Cyclooxygenases and lipoxygenases in cancer

C Schneider, A Pozzi - Cancer and Metastasis Reviews, 2011 - Springer
Cancer initiation and progression are multistep events that require cell proliferation,
migration, extravasation to the blood or lymphatic vessels, arrest to the metastatic site, and …