Post-translational acetylation of lysine residues has emerged as a key regulatory
mechanism in all eukaryotic organisms. Originally discovered in 1963 as a unique …

The biosynthesis of ribosomes is a complex process that requires the coordinated action of
many factors and a huge energy investment from the cell. Ribosomes are essential for …

Besides the canonical function in ribosome biogenesis, there have been significant recent
advances towards the fascinating roles of the nucleolus in stress response, cell destiny …

Genetic alterations impacting ubiquitously expressed proteins involved in RNA metabolism
often result in neurodegenerative conditions, with increasing evidence suggesting that …

Nucleoli are the sites where synthesis of rRNA and ribosomal assembly take place. Along
with these “traditional” roles, the nucleolus controls cellular physiology and homeostasis …

The cell nucleus is a major site for polyglutamine (polyQ) toxicity, but the underlying
mechanisms involved have yet been fully elucidated. Here, we report that mutant RNAs that …

Although, the nucleolus has been observed for almost 200 years in neurons, studies that
directly address the neuronal roles of this subnuclear structure have appeared only recently …

The acetylation of histone and non-histone proteins controls a great deal of cellular
functions, thereby affecting the entire organism, including the brain. Acetylation …

Transcriptional dysregulation in Huntington's disease (HD) is an early event that shapes the
brain transcriptome by both the depletion and ectopic activation of gene products that …

Abstract Polyglutamine binding protein 5 (PQBP5), also called nucleolar protein 10
(NOL10), binds to polyglutamine tract sequences and is expressed in the nucleolus. Using …