Glioblastoma (GBM) is the most malignant of astrocytomas mainly involving the cerebral
hemispheres and the cerebral cortex. It is one of the fatal and refractory solid tumors, with a …

Over the last decade, targeted alpha therapy has demonstrated its high effectiveness in
treating various oncological diseases. Lead-212, with a convenient half-life of 10.64 h, and …

Blood-brain barrier (BBB) dis-integrity, a characteristic of extensive inflammatory
encephalopathy, provides the access for brain-targeted drug delivery. Inspired from the …

Nano-drug delivery systems (NDDS) are functional drug-loaded nanocarriers widely applied
in cancer therapy. Recently, layer-by-layer (LbL) assembled NDDS have been …

Abstract Introduction 203 Pb (t 1/2= 51.9 h, 279 keV (81%)) is a diagnostic SPECT imaging
radionuclide ideally suited for theranostic applications in combination with 212 Pb for …

Production of medical radionuclides with ISOL facilities is a unique production method that
may provide access to preclinical quantities of some rare and potent radionuclides for …

Receptor-targeted image-guided Radionuclide Therapy (TRT) is increasingly recognized as
a promising approach to cancer treatment. In particular, the potential for clinical translation of …

Metastatic tumours in the brain now represent one of the leading causes of death from
cancer. Current treatments are largely ineffective owing to the combination of late diagnosis …

Brain metastases (BMs) frequently occur in primary tumors such as lung cancer, breast
cancer, and melanoma, and are associated with notably short natural survival. In addition to …

Despite improvements in extracranial therapy, survival rate for patients suffering from brain
metastases remains very poor. This is coupled with the incidence of brain metastases …