Since their discovery in the late 1970s, protein kinase C (PKC) isozymes represent one of
the most extensively studied signaling kinases. PKCs signal through multiple pathways and …

A link between T cell proliferation and the protein kinase C (PKC) family of serine/threonine
kinases has been recognized for about 30 years. However, despite the wealth of information …

Protein kinase C (PKC) is a family of phospholipid‐dependent serine/threonine kinases,
which can be further classified into three PKC isozymes subfamilies: conventional or classic …

PKC comprises a large family of serine/threonine kinases that share a requirement for
allosteric activation by lipids. While PKC isoforms have significant homology, functional …

Protein kinase C α (PKCα) is a ubiquitously expressed member of the PKC family of
serine/threonine kinases with diverse functions in normal and neoplastic cells. Early studies …

Protein kinase C (PKC) isozymes are commonly recognized as oncoproteins based on their
activation by tumor-promoting phorbol esters. However, accumulating evidence indicates …

Protein kinase C alpha (PKCα) can activate both pro-and anti-tumorigenic signaling
depending upon cellular context. Here, we investigated the role of PKCα in lung …

Protein kinase C (PKC) is a multifunctional family of Ser-Thr kinases widely implicated in the
regulation of fundamental cellular functions, including proliferation, polarity, motility, and …

Despite our extensive knowledge on the biology of protein kinase C (PKC) and its
involvement in disease, limited success has been attained in the generation of PKC isozyme …

We have previously shown that the serine/threonine kinase PKCα triggers MAPK/ERK
kinase (MEK)-dependent G 1→ S cell cycle arrest in intestinal epithelial cells, characterized …