The prefrontal cortex (PFC) plays an important role in the integration of cognitive and
affective behavior and regulating autonomic and neuroendocrine functions. This region of …

First described for their metabolic and immunosuppressive effects, glucocorticoids are
widely prescribed in clinical settings of inflammation. However, glucocorticoids are also …

Gray matter brain structures, including deep nuclei and the cerebral cortex, are affected
significantly and early in the course of multiple sclerosis and these changes may not be …

The immunosuppressive nature of glucocorticoids has been well documented both in vitro
and in vivo. This glucocorticoid-mediated immunosuppression has also been observed in …

Nowadays depression is considered as a systemic illness with different biological
mechanisms involved in its etiology, including inflammatory response, hypothalamic …

In this review, we summarize and discuss recent studies on structural plasticity changes,
particularly apoptosis, in the mammalian hippocampus in relation to stress and depression …

Stressful stimuli in healthy subjects trigger activation of a consistent and reproducible set of
brain regions; yet, the notion that there is a single and constant stress neuromatrix is not …

Maladaptive responses to stress and the associated hypersecretion of glucocorticoids cause
psychopathologies ranging from hyperemotional states and mood dysfunction to cognitive …

Early life stress, in the form of MD (24 h at pnd 9), interferes with brain developmental
trajectories modifying both behavioral and neurobiochemical parameters. MD has been …

An important question arising from previous observations in vivo is whether glucocorticoids
can directly influence neuronal survival in the hippocampus. To this end, a primary postnatal …