It has been established that oxidative stress, defined as the condition in which the sum of
free radicals in a cell exceeds the antioxidant capacity of the cell, contributes to the …

BACKGROUND: The cytosolic glutathione transferases (GSTs) comprise a super family of
proteins that can be categorized into multiple classes with a mixture of highly specific and …

Oxidative stress has been proposed to be an important factor in the pathogenesis of
Alzheimer's disease (AD) and contributed to β-amyloid (A β) generation. Interaction between …

Alzheimer's disease (AD) genetics may be one of the most prolifically published areas in
medicine and biology. Three early-onset AD genes with causative mutations (APP, PSEN1 …

The mercapturic acid pathway is a major route for the biotransformation of xenobiotic and
endobiotic electrophilic compounds and their metabolites. Mercapturic acids (N-acetyl-l …

Mitochondria play a critical role in several metabolic processes and apoptotic pathways,
regulating life cycle from the cradle to the grave. Despite the evidence of morphological …

As a major neuron type in the brain, the excitatory neuron (EN) regulates the lifespan in C.
elegans. How the EN acquires senescence, however, is unknown. Here, we show that …

The glutathionylation of intracellular protein thiols can protect against irreversible oxidation
and can act as a redox switch regulating metabolic pathways. In this study we discovered …

Abstract Interleukin‐1 (IL‐1) is a proinflammatory cytokine released by many cell types that
acts in both an autocrine and/or paracrine fashion. While IL‐1 is best described as an …

Genetic factors have a variable impact on Alzheimer's Disease (AD), ranging from familial
forms that are transmitted in an autosomal dominant fashion to sporadic AD, where a …