Among many, the oral route of delivery is considered to be the most favorable route with the
highest patient compliance. The main issue with oral delivery is the environmental …

Abstract Approximately 40% and 90% of the drugs developed and in the developing phase,
suffer from poor aqueous solubility, and thereby exhibiting declined oral bioavailability and …

Vascular disorders, characterized by vascular endothelial dysfunction combined with
inflammation, are correlated with numerous fatal diseases, such as coronavirus disease-19 …

Celastrol (CST) is a promising natural drug of herbal origin that gained a great interest in the
recent years by virtue of its wide variety of pharmacological actions. Nowadays, CST is …

The purpose of the present study was to develop febuxostat nanosuspension and
investigate its effect on febuxostat solubility, dissolution rate and oral bioavailability. The wet …

The study's primary goal was to enhance medicinal potential of piperine (PIP)-loaded
zeolitic imidazolate frameworks-8 (PIP@ ZIF-8) against doxorubicin (DOX)-induced …

In the present study, a phospholipid-based complex of standardized Centella extract (SCE)
was developed with a goal of improving the bioavailability of its phytoconstituents. The SCE …

Localized delivery of chemotherapeutic agents to treat breast cancer could limit their
adverse drug reactions. The aim of this study was to investigate the influence of physico …

Quercetin (QT) is a natural flavonoid with various biological activities and pharmacological
actions. However, the bioavailability of QT is relatively low due to its low solubility which …

Cartilage deterioration is the hallmark of osteoarthritis (OA). Rapid clearance of intra-
articularly injected drugs and inherent cartilage barrier properties represent enormous …