The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …

Forming the inner layer of the vascular system, endothelial cells (ECs) facilitate a multitude
of crucial physiological processes throughout the body. Vascular ECs enable the vessel wall …

The etiology of hypertension involves complex interactions among genetic, environmental,
and pathophysiologic factors that influence many regulatory systems. Hypertension is …

Hypertension is a major cardiovascular risk factor. Of the many processes involved in the
pathophysiology of hypertension, vascular damage due to oxidative stress (excess …

For a long time fruits and vegetables have been the target of many studies and have been
greatly promoted due to their nutritional value and abundance of bioactive compounds …

2 Hypertension May 2018 acknowledged in VSMCs, whether it has any significance in
vascular pathophysiology linked to angiotensin II had not been studied. Recently, our group …

The multifaceted nature of the renin-angiotensin system (RAS) makes it versatile due to its
involvement in pathogenesis of the cardiovascular disease. Angiotensin II (Ang II), a …

Cardiovascular diseases (CVDs) are the main contributors to global morbidity and mortality.
Major pathogenic phenotypes of CVDs include the development of endothelial dysfunction …

While effective treatments for acute respiratory distress syndrome (ARDS) are lacking,
mechanical lung ventilation can sustain adequate gas exchange in critically ill patients with …

Diabetic foot ulcers (DFUs) are significant complications of diabetes and an unmet medical
need. Matrix metalloproteinases (MMPs) play important roles in the pathology of wounds …