lipoxygenase (12/15-LOX) is an enzyme, which oxidizes polyunsaturated fatty acids,
particularly omega-6 and-3 fatty acids, to generate a number of bioactive lipid metabolites. A …

Linoleic acid (LA) is the most abundant polyunsaturated fatty acid found in the Western diet.
Cytochrome P450-derived LA metabolites 9, 10-epoxyoctadecenoic acid (9, 10-EpOME), 12 …

Maize kernel oil is a valuable source of nutrition. Here we extensively examine the genetic
architecture of maize oil biosynthesis in a genome-wide association study using 1.03 million …

Oxysterols are cholesterol metabolites that can be produced through enzymatic or radical
processes. They constitute a large family of lipids (ie the oxysterome) involved in a plethora …

The presence of epoxyeicosatrienoic acids (EETs) in tissues and their metabolism by
soluble epoxide hydrolase (sEH) to 1, 2-diols were first reported 30 years ago. However …

Parkinson's disease (PD) is one of the most common neurodegenerative disorders and is
characterized by loss of dopaminergic neurons in the substantia nigra (SN), causing …

The cardiovascular effects of epoxyeicosatrienoic acids (EETs) include vasodilation,
antimigratory actions on vascular smooth muscle cells and anti-inflammatory actions. These …

Metabolic syndrome (MetS) is a highly prevalent disease cluster worldwide. It requires
polypharmacological treatment of the single conditions including type II diabetes …

Polyunsaturated fatty acids (PUFA) are oxidized by cytochrome P450 epoxygenases to
PUFA epoxides which function as potent lipid mediators. The major metabolic pathways of …

Epoxyeicosatrienoic acids (EETs) are arachidonic acid metabolites that importantly
contribute to vascular and cardiac physiology. The contribution of EETs to vascular and …