Highlights•Genomics analyses to identify the targets of cancer immunoediting and design
personalized cancer immunotherapy.•Emerging role of innate immune cells (NK, DC …

The observation that a subset of cancer patients show evidence for spontaneous CD8+ T
cell priming against tumor-associated antigens has generated renewed interest in the innate …

NKG2D is an activating receptor expressed by all NK cells and subsets of T cells. It serves
as a major recognition receptor for detection and elimination of transformed and infected …

The presence of inflammatory immune cells in human tumors raises a fundamental question
in oncology: How do cancer cells avoid the destruction by immune attack? In principle, tumor …

In recent years, roles of the immune system in immune surveillance of cancer have been
explored using a variety of approaches. The roles of the adaptive immune system have been …

Cellular senescence is a stress response mechanism that limits tumorigenesis and tissue
damage. Induction of cellular senescence commonly coincides with an immunogenic …

The importance of the immune system in conferring protection against pathogens like
viruses, bacteria, and parasitic worms is well established. In contrast, there is a long-lasting …

A recombinant vaccine containing Aventis Pasteur's canarypox vector (ALVAC)–HIV and
gp120 alum decreased the risk of HIV acquisition in the RV144 vaccine trial. The substitution …

Protection against cellular stress from various sources, such as nutritional, physical,
pathogenic, or oncogenic, results in the induction of both intrinsic and extrinsic cellular …

Multiple myeloma (MM) is an age-dependent hematological malignancy. Evaluation of
immune interactions that drive MM relies on in vitro experiments that do not reflect the …