Background Physical inactivity increases the risk for metabolic diseases such as obesity and
type 2 diabetes. Neuromuscular electrical stimulation (NMES) is an effective method to …

The two closely related RabGAPs TBC1D1 and TBC1D4 are key signaling factors of skeletal
muscle substrate utilization. In mice, deficiency in both RabGAPs leads to reduced skeletal …

We hypothesized that skeletal muscle contraction produces a cellular stress signal,
triggering adipose tissue lipolysis to sustain fuel availability during exercise. The present …

Aberrant lipid metabolism promotes the development of skeletal muscle insulin resistance,
but the exact identity of lipid-mediated mechanisms relevant to human obesity remains …

Exercise is a first-line treatment for type 2 diabetes and preserves β-cell function by hitherto
unknown mechanisms. We postulated that proteins from contracting skeletal muscle may act …

Context Maternal exercise positively influences pregnancy outcomes and metabolic health
in progeny; however, data regarding the effects of different modes of prenatal exercise on …

Type 2 diabetes is more prevalent in African American (AA) than Caucasian (C) adults.
Furthermore, differential substrate utilization has been observed between AA and C adults …

Context Recent preclinical data suggest exercise during pregnancy can improve the
metabolic phenotype not only of the mother, but of the developing offspring as well …

Healthy mitochondrial networks are maintained via balanced integration of mitochondrial
quality control processes (biogenesis, fusion, fission, and mitophagy). The purpose of this …

Objective In adults, skeletal muscle insulin sensitivity (SI) and fatty acid oxidation (FAO) are
linked with a predisposition to obesity. The current study aimed to determine the effects of …