Biomedical applications of calixarenes: state of the art and perspectives

YC Pan, XY Hu, DS Guo - Angewandte Chemie International …, 2021 - Wiley Online Library
Calixarenes (CAs), representing the third generation of supramolecular hosts and one of the
most widely studied macrocyclic scaffolds, offer (almost) unlimited structure and application …

Recent updates on development of protein-tyrosine phosphatase 1B inhibitors for treatment of diabetes, obesity and related disorders

S Singh, AS Grewal, R Grover, N Sharma, B Chopra… - Bioorganic …, 2022 - Elsevier
The aim of this review was to discuss an overview of type 2 diabetes; biology of PTP1B; role
of PTP1B in metabolic disorders; and recent updates in the development of PTP1B inhibitors …

Applications of calixarenes in cancer chemotherapy: facts and perspectives

A Yousaf, SA Hamid, NM Bunnori… - … design, development and …, 2015 - Taylor & Francis
Research on the therapeutic applications of calixarene derivatives is an emerging area of
interest. The anticancer activity of various functionalized calixarenes has been reported by …

Functionalized calix [4] arenes as potential therapeutic agents

MM Naseer, M Ahmed… - Chemical biology & drug …, 2017 - Wiley Online Library
Calixarenes, composed of phenolic units linked by methylene bridges at the 2, 6‐positions,
represent a versatile class of macrocyclic compounds in supramolecular chemistry that can …

Host-Guest Complexation of Oxaliplatin and Para-Sulfonatocalix[n]Arenes for Potential Use in Cancer Therapy

SA Fahmy, F Ponte, IM Fawzy, E Sicilia, U Bakowsky… - Molecules, 2020 - mdpi.com
P-sulfonatocalix [n] arenes have demonstrated a great potential for encapsulation of
therapeutic drugs via host-guest complexation to improve solubility, stability, and …

Anionic amphiphilic calixarenes for peptide assembly and delivery

RV Rodik, SO Cherenok, VY Postupalenko… - Journal of Colloid and …, 2022 - Elsevier
Shape-persistent macrocycles enable superior control on molecular self-assembly, allowing
the preparation of well-defined nanostructures with new functions. Here, we report on …

Investigation of the host-guest complexation between 4-sulfocalix [4] arene and nedaplatin for potential use in drug delivery

SA Fahmy, F Ponte, MK Abd El-Rahman… - … Acta Part A: Molecular …, 2018 - Elsevier
Macromolecules including macrocyclic species have been reported to have the potential to
encapsulate biologically active compounds such as drugs through host-guest complexation …

Calixarene-based pure and mixed assemblies for biomedical applications

Y Razuvayeva, R Kashapov… - Supramolecular …, 2020 - Taylor & Francis
The spontaneous preparation of well-defined functional nanoscale systems is very
important, since this formulation process requires additional resources, external supply of …

The design strategy of selective PTP1B inhibitors over TCPTP

XQ Li, LJ Wang, DY Shi - Bioorganic & medicinal chemistry, 2016 - Elsevier
Protein tyrosine phosphatase 1B (PTP1B) has already been well studied as a highly
validated therapeutic target for diabetes and obesity. However, the lack of selectivity limited …

Calixarene-based phosphinic acids as inhibitors of protein tyrosine phosphatases

VM Buldenko, VV Trush, OL Kobzar… - Bioorganic & medicinal …, 2019 - Elsevier
In the present work, the derivatives of calix [4] arene, thiacalix [4] arene, and sulfonylcalix [4]
arene bearing four methylene (phenyl) phosphinic acid groups on the upper rim of the …