Strategies for transporting nanoparticles across the blood–brain barrier
The existence of blood–brain barrier (BBB) hampers the effective treatment of central
nervous system (CNS) diseases. Almost all macromolecular drugs and more than 98% of …
nervous system (CNS) diseases. Almost all macromolecular drugs and more than 98% of …
[HTML][HTML] The paradox of HIV blood–brain barrier penetrance and antiretroviral drug delivery deficiencies
HIV attacks the body's immune cells, frequently compromises the integrity of the blood–brain
barrier (BBB), and infects the CNS in the early stages of infection. Dysfunction of the BBB …
barrier (BBB), and infects the CNS in the early stages of infection. Dysfunction of the BBB …
Collagen nanofiber containing silver nanoparticles for improved wound-healing applications
Electrospun nanofibers showing great promise for fabricating nanostructured materials
might help to improve the quality of wound care. The present study aimed to investigate the …
might help to improve the quality of wound care. The present study aimed to investigate the …
Pharmaceutical polymers and P-glycoprotein: Current trends and possible outcomes in drug delivery
Drug resistance is considered a key reason behind the failure of therapeutic medications in
treating chronic diseases, including hypertension, cancer therapeutics, and antimicrobial …
treating chronic diseases, including hypertension, cancer therapeutics, and antimicrobial …
Advances in nanotechnology-based carrier systems for targeted delivery of bioactive drug molecules with special emphasis on immunotherapy in drug resistant …
From the early sixteenth and seventeenth centuries to the present day of life, tuberculosis
(TB) still is a global health threat with some new emergence of resistance. This type of …
(TB) still is a global health threat with some new emergence of resistance. This type of …
Deoxycholic acid-functionalised nanoparticles for oral delivery of rhein
W Yao, Z Xu, J Sun, J Luo, Y Wei, J Zou - European Journal of …, 2021 - Elsevier
Rhein (RH) is a candidate for the treatment of kidney diseases. However, clinical application
of RH is impeded by low aqueous solubility and oral bioavailability. Deoxycholic acid …
of RH is impeded by low aqueous solubility and oral bioavailability. Deoxycholic acid …
Use of novel taurine-chitosan mediated liposomes for enhancing the oral absorption of doxorubicin via the TAUT transporter
S Qin, Z Wen, H Huang, W Wu - Carbohydrate Polymers, 2024 - Elsevier
Our research aimed to enhance the oral bioavailability of doxorubicin hydrochloride (DOX·
HCl) while minimizing the potential for myocardial toxicity. To achieve this goal, we …
HCl) while minimizing the potential for myocardial toxicity. To achieve this goal, we …
The blood–brain barrier and beyond: Nano-based neuropharmacology and the role of extracellular matrix
P Henrich-Noack, D Nikitovic, M Neagu… - … , Biology and Medicine, 2019 - Elsevier
Restrained drug delivery due to the blood–brain barrier (BBB) considerably limits options for
the treatment of brain pathologies. The utilization of nanoparticulate (NP) carriers has been …
the treatment of brain pathologies. The utilization of nanoparticulate (NP) carriers has been …
Sericin nanomicelles with enhanced cellular uptake and pH-triggered release of doxorubicin reverse cancer drug resistance
Drug resistance is the major challenge facing cancer chemotherapy and nanoscale delivery
systems based on natural materials, such as sericin, are a promising means of overcoming …
systems based on natural materials, such as sericin, are a promising means of overcoming …
Enhanced reactive oxygen species generation by mitochondria targeting of anticancer drug to overcome tumor multidrug resistance
Y Liu, Z Zhou, X Lin, X Xiong, R Zhou, M Zhou… - …, 2019 - ACS Publications
As a major clinical tumor chemotherapeutic burden, multidrug resistance (MDR) is often a
result of up-regulation of P-glycoprotein (P-gp), which strongly enhances anticancer drug …
result of up-regulation of P-glycoprotein (P-gp), which strongly enhances anticancer drug …