Advances in genome sequencing technologies have created new opportunities for
comparative primate genomics. Genome assemblies have been published for various …

Recent genome sequencing efforts in a variety of cancers have revealed mutations and/or
structural alterations in ATRX and DAXX, which together encode a complex that deposits …

Noncoding DNA is central to our understanding of human gene regulation and complex
diseases,, and measuring the evolutionary sequence constraint can establish the functional …

Abstract Cys2-His2 zinc finger (C2H2-ZF) proteins represent the largest class of putative
human transcription factors. However, for most C2H2-ZF proteins it is unknown whether they …

Cys2-His2 zinc finger genes (ZNFs) form the largest family of transcription factors in
metazoans. ZNF evolution is highly dynamic and characterized by the rapid expansion and …

TFClass aims at classifying eukaryotic transcription factors (TFs) according to their DNA-
binding domains (DBDs). For this, a classification schema comprising four generic levels …

The origination of new genes contributes to phenotypic evolution in humans. Two major
challenges in the study of new genes are the inference of gene ages and annotation of their …

The form that an animal takes during development is directed by gene regulatory networks
(GRNs). Developmental GRNs interpret maternally deposited molecules and externally …

Nuclear hormone receptors (NRs) are evolutionarily conserved ligand-dependent
transcription factors. They are essential for human life, mediating the actions of lipophilic …

Much is known about vertebrate DNA methylation, however it is not known how methylated
CpG within particular sequences is recognized. Two recent structures of C2H2 zinc finger …