There are four sequenced and publicly available plant genomes to date. With many more
slated for completion, one challenge will be to use comparative genomic methods to detect …

Astrocytes are glial cells that are abundant in the central nervous system (CNS) and that
have important homeostatic and disease-promoting functions. However, little is known about …

Multiple sclerosis is a chronic inflammatory disease of the CNS. Astrocytes contribute to the
pathogenesis of multiple sclerosis, but little is known about the heterogeneity of astrocytes …

DNA sequences that regulate expression of the insulin gene are located within a region
spanning∼ 400 bp that flank the transcription start site. This region, the insulin promoter …

Background Multiple genome alignment remains a challenging problem. Effects of
recombination including rearrangement, segmental duplication, gain, and loss can create a …

We have conducted a comprehensive search for conserved elements in vertebrate
genomes, using genome-wide multiple alignments of five vertebrate species (human …

Regulatory T cells (Treg) expressing the transcription factor Foxp3 control the autoreactive
components of the immune system. The development of Treg cells is reciprocally related to …

Genome-wide studies have identified genetic variants linked to neurologic diseases.
Environmental factors also play important roles, but no methods are available for their …

Despite continual progress in the cataloging of vertebrate regulatory elements, little is known
about their organization and regulatory architecture. Here we describe a massively parallel …

In spite of the extensive potential of human mesenchymal stem cells (hMSCs) in cell therapy,
little is known about the molecular mechanisms that regulate their therapeutic properties. We …