Sex differences in fear responses: Neural circuits

EP Bauer - Neuropharmacology, 2023 - Elsevier
Women have increased vulnerability to PTSD and anxiety disorders compared to men.
Understanding the neurobiological underpinnings of these disorders is critical for identifying …

Astrocyte regulation of synaptic signaling in psychiatric disorders

A Kruyer, PW Kalivas, MD Scofield - Neuropsychopharmacology, 2023 - nature.com
Over the last 15 years, the field of neuroscience has evolved toward recognizing the critical
role of astroglia in shaping neuronal synaptic activity and along with the pre-and …

A neural substrate of compulsive alcohol use

E Domi, L Xu, S Toivainen, A Nordeman, F Gobbo… - Science …, 2021 - science.org
Alcohol intake remains controlled in a majority of users but becomes “compulsive,” ie,
continues despite adverse consequences, in a minority who develop alcohol addiction …

Spatiotemporal reorganization of corticostriatal networks encodes motor skill learning

N Badreddine, G Zalcman, F Appaix, G Becq… - Cell reports, 2022 - cell.com
Motor skill learning requires the activity of the dorsal striatum, with a differential global
implication of the dorsomedial and dorsolateral territories. We investigate here whether and …

Sex differences in the rodent medial prefrontal cortex–What Do and Don't we know?

MA Laine, EM Greiner, RM Shansky - Neuropharmacology, 2024 - Elsevier
The prefrontal cortex, particularly its medial subregions (mPFC), mediates critical functions
such as executive control, behavioral inhibition, and memory formation, with relevance for …

Reactivation of encoding ensembles in the prelimbic cortex supports temporal associations

TB Santos, CA de Oliveira Coelho… - …, 2024 - nature.com
Fear conditioning is encoded by strengthening synaptic connections between the neurons
activated by a conditioned stimulus (CS) and those activated by an unconditioned stimulus …

Technologies for large-scale mapping of functional neural circuits active during a user-defined time window

NV Barykina, MM Karasev, VV Verkhusha… - Progress in …, 2022 - Elsevier
The mapping of neural circuits activated during behavior down to individual neurons is
crucial for decoding how the brain processes information. Technologies allowing activity …

Glutamatergic neurotransmission controls the functional lateralization of the mPFC in the modulation of anxiety induced by social defeat stress in male mice

N Santos-Costa, D Baptista-de-Souza… - Frontiers in Behavioral …, 2021 - frontiersin.org
The rodent medial prefrontal cortex (mPFC) is anatomically divided into cingulate (Cg1),
prelimbic (PrL), and infralimbic (IL) subareas. The left and right mPFC (L and RmPFC) …

Sex-specific neural networks of cued threat conditioning: a pilot study

KC du Plessis, S Basu, TH Rumbell… - Frontiers in Systems …, 2022 - frontiersin.org
Cued threat conditioning is the most common preclinical model for emotional memory, which
is dysregulated in anxiety disorders and post-traumatic stress disorder. Though women are …

Pain-related neuronal ensembles in the primary somatosensory cortex contribute to hyperalgesia and anxiety

T Ishikawa, K Murata, H Okuda, I Potapenko, K Hori… - Iscience, 2023 - cell.com
The mechanism by which acute pain or itch information at the periphery is processed in the
primary somatosensory cortex (S1) remains unclear. To elucidate this, we used a viral …