Neural correlates of unconsciousness in large-scale brain networks
GA Mashour, AG Hudetz - Trends in neurosciences, 2018 - cell.com
The biological basis of consciousness is one of the most challenging and fundamental
questions in 21st century science. A related pursuit aims to identify the neural correlates and …
questions in 21st century science. A related pursuit aims to identify the neural correlates and …
Minimum alveolar concentration: ongoing relevance and clinical utility
A Aranake, GA Mashour, MS Avidan - Anaesthesia, 2013 - Wiley Online Library
Since its introduction in 1965, minimum alveolar concentration (MAC) has served as the
standard measure of potency for volatile anaesthetic agents. It is defined as the minimum …
standard measure of potency for volatile anaesthetic agents. It is defined as the minimum …
Stratification of unresponsive patients by an independently validated index of brain complexity
Objective Validating objective, brain‐based indices of consciousness in behaviorally
unresponsive patients represents a challenge due to the impossibility of obtaining …
unresponsive patients represents a challenge due to the impossibility of obtaining …
[HTML][HTML] Consciousness and complexity during unresponsiveness induced by propofol, xenon, and ketamine
A common endpoint of general anesthetics is behavioral unresponsiveness [1], which is
commonly associated with loss of consciousness. However, subjects can become …
commonly associated with loss of consciousness. However, subjects can become …
Reflections on palliative sedation
R Twycross - Palliative Care: Research and Treatment, 2019 - journals.sagepub.com
'Palliation sedation'is a widely used term to describe the intentional administration of
sedatives to reduce a dying person's consciousness to relieve intolerable suffering from …
sedatives to reduce a dying person's consciousness to relieve intolerable suffering from …
Disruption of thalamic functional connectivity is a neural correlate of dexmedetomidine-induced unconsciousness
Understanding the neural basis of consciousness is fundamental to neuroscience research.
Disruptions in cortico-cortical connectivity have been suggested as a primary mechanism of …
Disruptions in cortico-cortical connectivity have been suggested as a primary mechanism of …
Brain functional connectivity differentiates dexmedetomidine from propofol and natural sleep
P Guldenmund, A Vanhaudenhuyse… - BJA: British Journal …, 2017 - academic.oup.com
Background We used functional connectivity measures from brain resting state functional
magnetic resonance imaging to identify human neural correlates of sedation with …
magnetic resonance imaging to identify human neural correlates of sedation with …
Disconnecting consciousness: is there a common anesthetic end point?
AG Hudetz, GA Mashour - Anesthesia & Analgesia, 2016 - journals.lww.com
In this article, we review (1) the importance of information integration in consciousness,(2)
early studies of network breakdown during anesthesia,(3) preclinical research …
early studies of network breakdown during anesthesia,(3) preclinical research …
[HTML][HTML] Distinct EEG signatures differentiate unconsciousness and disconnection during anaesthesia and sleep
Background How conscious experience becomes disconnected from the environment, or
disappears, across arousal states is unknown. We sought to identify the neural correlates of …
disappears, across arousal states is unknown. We sought to identify the neural correlates of …
Are we really unconscious in “unconscious” states? Common assumptions revisited
In the field of consciousness science, there is a tradition to categorize certain states such as
slow-wave non-REM sleep and deep general anesthesia as “unconscious”. While this …
slow-wave non-REM sleep and deep general anesthesia as “unconscious”. While this …