Statins, among the most commonly prescribed drugs worldwide, are cholesterol-lowering
agents used to manage and prevent cardiovascular and coronary heart diseases. Recently …

Learning Objectives After completing this course, the reader will be able to: Explain how
statins, used in the treatment of hypercholesterolemia, may be applicable to cancer …

Background Accumulating evidence suggests that statins affect diseases other than
cardiovascular disease, including cancer, and that these effects may depend on the lipid …

Statins are inhibitors of 3-hydroxy-methylglutaryl (HMG) CoA reductase. They exhibit effects
beyond cholesterol reduction, including anticancer activity. This review presents the effects …

The mevalonate pathway is a core biochemical process, crucial for the generation of
cholesterol and other key metabolic end products. The rate-limiting enzyme of the …

Hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, also called statins, are
commonly prescribed medications that lower serum cholesterol and decrease cardiac …

Statins are inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), which
is a rate-limiting enzyme in the mevalonate pathway. The pleiotropic effects of statins may be …

Renal cell carcinoma (RCC) is the most lethal type of genitourinary cancer due to its occult
onset and resistance to chemotherapy and radiation. Recently, accumulating evidence has …

Purpose There has been growing interest in the potential anticancer activity of statins based
on preclinical evidence of their antiproliferative, proapoptotic, and radiosensitizing …

Background Colorectal cancer (CRC) remains one of the most common types of cancer and
a leading cause of death worldwide. Previous studies indicated that statins may have a …