The compartmentalization of eukaryotic cells is reliant on the fidelity of vesicle-mediated
intracellular transport. Vesicles deliver their cargo via membrane fusion, a process requiring …

Protein coding mutations in leucine‐rich repeat kinase 2 (LRRK2) cause familial Parkinson's
disease (PD), and noncoding variations around the gene increase the risk of developing …

INTRODUCTION Protein-protein interactions play critical roles in biology, but the structures
of many eukaryotic protein complexes are unknown, and there are likely many interactions …

Lysosomes are essential for cellular recycling, nutrient signaling, autophagy, and
pathogenic bacteria and viruses invasion. Lysosomal fusion is fundamental to cell survival …

The exocyst is an evolutionarily conserved octameric protein complex that mediates the
tethering of post-Golgi secretory vesicles to the plasma membrane during exocytosis and is …

The exocyst is a conserved octameric complex that tethers exocytic vesicles to the plasma
membrane prior to fusion. Exocyst assembly and delivery mechanisms remain unclear …

Multisubunit tethering complexes (MTCs) are multitasking hubs that form a link between
membrane fusion, organelle motility and signaling. CORVET, CHEVI and HOPS are MTCs of …

The effectors of the Rab7 small GTPase play multiple roles in Rab7-dependent endosome-
lysosome and autophagy-lysosome pathways. However, it is largely unknown how distinct …

The autophagosomal SNARE Syntaxin17 (Syx17) forms a complex with Snap29 and
Vamp7/8 to promote autophagosome-lysosome fusion via multiple interactions with the …

Eukaryotic cells possess a remarkably diverse range of organelles that provide
compartmentalization for distinct cellular functions and are likely responsible for the …