Multienzyme‐like nanozymes: regulation, rational design, and application

J Sheng, Y Wu, H Ding, K Feng, Y Shen… - Advanced …, 2024 - Wiley Online Library
Nanomaterials with more than one enzyme‐like activity are termed multienzymic
nanozymes, and they have received increasing attention in recent years and hold huge …

Activity regulating strategies of nanozymes for biomedical applications

X Ding, Z Zhao, Y Zhang, M Duan, C Liu, Y Xu - Small, 2023 - Wiley Online Library
On accounts of the advantages of inherent high stability, ease of preparation and superior
catalytic activities, nanozymes have attracted tremendous potential in diverse biomedical …

Enzyme-mimetic antioxidant nanomaterials for ROS scavenging: Design, classification, and biological applications

S Zhou, H Cai, X He, Z Tang, S Lu - Coordination Chemistry Reviews, 2024 - Elsevier
Reactive oxygen species (ROS) perform vital functions in numerous life processes and
significantly affect physiological activities in different organ systems in the human body …

Metal‐Based Nanozymes with Multienzyme‐Like Activities as Therapeutic Candidates: Applications, Mechanisms, and Optimization Strategy

D Li, D Dai, G Xiong, S Lan, C Zhang - Small, 2023 - Wiley Online Library
Most nanozymes in development for medical applications only exhibit single‐enzyme‐like
activity, and are thus limited by insufficient catalytic activity and dysfunctionality in complex …

Immunotoxicity of metal and metal oxide nanoparticles: from toxic mechanisms to metabolism and outcomes

J Bi, C Mo, S Li, M Huang, Y Lin, P Yuan, Z Liu… - Biomaterials …, 2023 - pubs.rsc.org
The influence of metal and metal oxide nanomaterials on various fields since their discovery
has been remarkable. They have unique properties, and therefore, have been employed in …

Mn− Ce Symbiosis: Nanozymes with Multiple Active Sites Facilitate Scavenging of Reactive Oxygen Species (ROS) Based on Electron Transfer and Confinement …

J Zhang, Z Wang, X Lin, X Gao, Q Wang… - Angewandte Chemie …, 2024 - Wiley Online Library
Regulating appropriate valence states of metal active centers, such as Ce3+/Ce4+ and
Mn3+/Mn2+, as well as surface vacancy defects, is crucial for enhancing the catalytic activity …

Multifunctional gold clusterzymes with distinct glucose depletion and macrophage reprogramming capability towards regulating the regeneration cascade

T Wang, Z Xu, M Wen, N Li, L Zhang, Y Xue… - Chemical Engineering …, 2024 - Elsevier
Treating diabetic wounds remains a significant clinic challenge nowadays, where one of the
major hurdles is hyperglycemia. Particularly, hyperglycemia sets off a cascade of changes in …

[HTML][HTML] Stem cell-derived hepatocyte therapy using versatile biomimetic nanozyme incorporated nanofiber-reinforced decellularized extracellular matrix hydrogels for …

Y Jin, J Zhang, Y Xu, K Yi, F Li, H Zhou, H Wang… - Bioactive Materials, 2023 - Elsevier
Reactive oxygen species (ROS)-associated oxidative stress, inflammation storm, and
massive hepatocyte necrosis are the typical manifestations of acute liver failure (ALF) …

Transition-Metal-Based Nanozymes: Synthesis, Mechanisms of Therapeutic Action, and Applications in Cancer Treatment

Q Fu, C Wei, M Wang - ACS nano, 2024 - ACS Publications
Cancer, as one of the leading causes of death worldwide, drives the advancement of cutting-
edge technologies for cancer treatment. Transition-metal-based nanozymes emerge as …

Advances in antioxidant nanozymes for biomedical applications

X Liu, H Xu, H Peng, L Wan, D Di, Z Qin, L He… - Coordination Chemistry …, 2024 - Elsevier
Antioxidant nanozymes have garnered significant attention due to their high stability, ease of
modification, and low cost, which overcome the limitations of natural enzymes. Although …