Inflammatory activation and/or dysfunction of the glomerular endothelium triggers proteinuria
in many systemic and localized vascular disorders. Among them are the thrombotic …

Lung cancer remains a major cause of cancer-related deaths worldwide with unfavourable
prognosis mainly due to the late stage of disease at presentation. High incidence and …

A critical event during kidney organogenesis is the differentiation of podocytes, specialized
epithelial cells that filter blood plasma to form urine. Podocytes derived from human …

Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes
diverse clinical manifestations and tissue injuries in multiple organs. However, cellular and …

Aberrant activation of the developing immune system can have long-term negative
consequences on cognition and behavior. Teratogens, such as alcohol, activate microglia …

Introduction Podocalyxin (gene name PODXL) is a CD34-related sialomucin implicated in
the regulation of cell adhesion, migration and polarity. Upregulated expression of …

Simple Summary Malignancies derived from epithelial cells account for over 90% of all
human cancers. Several aspects of cancer progression such as metastasis, immune …

β-escin is a mixture of triterpene saponins isolated from the horse chestnut seeds (Aesculus
hippocastanum L.). The anti-edematous, anti-inflammatory and venotonic properties of β …

Dominant and recessive mutations in podocalyxin (PODXL) are associated with human
kidney disease. Interestingly, some PODXL mutations manifest as anuria while others are …

Podocalyxin (Podxl) is broadly expressed on the luminal face of most blood vessels in adult
vertebrates, yet its function on these cells is poorly defined. In the present study, we …