Chronic pain resulting from nerve injury, tissue inflammation, and tumor invasion or
treatment, is a major health problem impacting the quality of life and producing a significant …

Chemokines are a large family of small secreted proteins that have fundamental roles in
organ development, normal physiology, and immune responses upon binding to their …

Chemokines are chemotactic cytokines whose canonical functions govern movement of
receptor-expressing cells along chemical gradients. Chemokines are a physiological system …

Simple Summary Cancer immunotherapy has now attracted much attention because of the
recent success of immune checkpoint inhibitors. However, they are only beneficial in a …

Highlights•Dynamic membrane protein interfaces, in particular in GPCRs suggest novel
regulatory and organizational paradigms.•Long timescale atomistic simulations give a …

Circular RNAs (circRNAs) are emerging as novel regulators in the biological development of
various diseases, but their expression profiles, functions and mechanisms in silicosis and …

The CXCL12 system is central to the development of many organs and is further crucially
engaged in pathophysiological processes underlying cancer, inflammation, and …

Chemokine receptors are the central signaling hubs of several processes such as cell
migration, chemotaxis and cell positioning. In this graphical review, we provide an overview …

Sexually antagonistic selection, which favours different optima in males and females, is
predicted to play an important role in the evolution of sex chromosomes. Body size is a …

Background Type 1 conventional dendritic cells (cDC1s) are characterized by their ability to
induce potent CD8+ T cell responses. In efforts to generate novel vaccination strategies …