Chemokines in chronic pain: cellular and molecular mechanisms and therapeutic potential
Chronic pain resulting from nerve injury, tissue inflammation, and tumor invasion or
treatment, is a major health problem impacting the quality of life and producing a significant …
treatment, is a major health problem impacting the quality of life and producing a significant …
Role of chemokine systems in cancer and inflammatory diseases
H Li, M Wu, X Zhao - MedComm, 2022 - Wiley Online Library
Chemokines are a large family of small secreted proteins that have fundamental roles in
organ development, normal physiology, and immune responses upon binding to their …
organ development, normal physiology, and immune responses upon binding to their …
Physiology of chemokines in the cancer microenvironment
D Drouillard, BT Craig… - American Journal of …, 2023 - journals.physiology.org
Chemokines are chemotactic cytokines whose canonical functions govern movement of
receptor-expressing cells along chemical gradients. Chemokines are a physiological system …
receptor-expressing cells along chemical gradients. Chemokines are a physiological system …
[HTML][HTML] Recent progress in dendritic cell-based cancer immunotherapy
Simple Summary Cancer immunotherapy has now attracted much attention because of the
recent success of immune checkpoint inhibitors. However, they are only beneficial in a …
recent success of immune checkpoint inhibitors. However, they are only beneficial in a …
Dynamic protein interfaces and conformational landscapes of membrane protein complexes
SA Kharche, D Sengupta - Current Opinion in Structural Biology, 2020 - Elsevier
Highlights•Dynamic membrane protein interfaces, in particular in GPCRs suggest novel
regulatory and organizational paradigms.•Long timescale atomistic simulations give a …
regulatory and organizational paradigms.•Long timescale atomistic simulations give a …
Identification of circRNA expression profiles and the potential role of hsa_circ_0006916 in silicosis and pulmonary fibrosis
Q Wu, B Jiao, Q Zhang, C Jin, H Yu, F Wang - Toxicology, 2023 - Elsevier
Circular RNAs (circRNAs) are emerging as novel regulators in the biological development of
various diseases, but their expression profiles, functions and mechanisms in silicosis and …
various diseases, but their expression profiles, functions and mechanisms in silicosis and …
Functions of the CXCL12 receptor ACKR3/CXCR7—what has been perceived and what has been overlooked
C Koch, J Engele - Molecular Pharmacology, 2020 - ASPET
The CXCL12 system is central to the development of many organs and is further crucially
engaged in pathophysiological processes underlying cancer, inflammation, and …
engaged in pathophysiological processes underlying cancer, inflammation, and …
Insights into the dynamic interactions at chemokine-receptor interfaces and mechanistic models of chemokine binding
A Sonawani, S Kharche, D Dasgupta… - Journal of Structural …, 2022 - Elsevier
Chemokine receptors are the central signaling hubs of several processes such as cell
migration, chemotaxis and cell positioning. In this graphical review, we provide an overview …
migration, chemotaxis and cell positioning. In this graphical review, we provide an overview …
Genomic basis of Y‐linked dwarfism in cichlids pursuing alternative reproductive tactics
Sexually antagonistic selection, which favours different optima in males and females, is
predicted to play an important role in the evolution of sex chromosomes. Body size is a …
predicted to play an important role in the evolution of sex chromosomes. Body size is a …
[HTML][HTML] Efficient targeting of NY-ESO-1 tumor antigen to human cDC1s by lymphotactin results in cross-presentation and antigen-specific T cell expansion
C Le Gall, A Cammarata, L de Haas… - … for Immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Background Type 1 conventional dendritic cells (cDC1s) are characterized by their ability to
induce potent CD8+ T cell responses. In efforts to generate novel vaccination strategies …
induce potent CD8+ T cell responses. In efforts to generate novel vaccination strategies …