CNS-resident macrophages—including parenchymal microglia and border-associated
macrophages (BAMs)—contribute to neuronal development and health, vascularization, and …

The increasing use of single-cell immune profiling and advanced microscopic imaging
technologies has deepened our understanding of the cardiac immune system, confirming …

Atherosclerotic plaques develop in the inner intimal layer of arteries and can cause heart
attacks and strokes. As plaques lack innervation, the effects of neuronal control on …

Understanding of the factors governing immune responses in cancer remains incomplete,
limiting patient benefit. In this study, we used mass cytometry to define the systemic immune …

In patients infected by SARS‐CoV‐2 who experience an exaggerated inflammation leading
to pneumonia, monocytes likely play a major role but have received poor attention. Thus, we …

Background Immunotherapy has revolutionized clinical outcomes for patients suffering from
lung cancer, yet relatively few patients sustain long-term durable responses. Recent studies …

Background Human carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1) is an
inhibitory cell surface protein that functions through homophilic and heterophilic ligand …

Our research over the past decade has compellingly demonstrated the potential of
Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) receptor agonists …

Cardiac macrophages represent a functionally diverse population of cells involved in
cardiac homeostasis, repair, and remodeling. With recent advancements in single-cell …

Conventional Ly6Chi monocytes have developmental plasticity for a spectrum of
differentiated phagocytes. Here we show, using conditional deletion strategies in a mouse …