Carbonic anhydrase and bacterial metabolism: a chance for antibacterial drug discovery

C Capasso, CT Supuran - Expert Opinion on Therapeutic Patents, 2024 - Taylor & Francis
ABSTRACT Introduction Carbonic anhydrases (CAs, EC 4.2. 1.1) play a pivotal role in the
regulation of carbon dioxide, bicarbonate, and hydrogen ions within bacterial cells, ensuring …

Type II bacterial toxin–antitoxins: hypotheses, facts, and the newfound plethora of the PezAT system

WT Chan, MP Garcillán-Barcia, CC Yeo… - FEMS Microbiology …, 2023 - academic.oup.com
Toxin–antitoxin (TA) systems are entities found in the prokaryotic genomes, with eight
reported types. Type II, the best characterized, is comprised of two genes organized as an …

Decoding bacterial persistence: mechanisms and strategies for effective eradication

A Sett, V Dubey, S Bhowmik… - ACS Infectious Diseases, 2024 - ACS Publications
The ability of pathogenic bacteria to evade antibiotic treatment is an intricate and
multifaceted phenomenon. Over the years, treatment failure among patients due to …

Bacterial persister cells and development of antibiotic resistance in chronic infections: an update

AP Kunnath, M Suodha Suoodh… - British Journal of …, 2024 - frontierspartnerships.org
The global issue of antimicrobial resistance poses significant challenges to public health.
The World Health Organization (WHO) has highlighted it as a major global health threat …

[HTML][HTML] Friends and foes: Bacteria of the hydroponic plant microbiome

BO Thomas, SL Lechner, HC Ross, BR Joris, BR Glick… - Plants, 2024 - mdpi.com
Hydroponic greenhouses and vertical farms provide an alternative crop production strategy
in regions that experience low temperatures, suboptimal sunlight, or inadequate soil quality …

Distribution patterns and influential factors of pathogenic bacteria in freshwater aquaculture sediments

W Xi, X Zhang, X Zhu, J Wang, H Xue, H Pan - Environmental Science and …, 2024 - Springer
Pathogenic bacteria, the major causative agents of aquaculture diseases, are a serious
impediment to the aquaculture industry. However, the bioinformatics of pathogenic bacteria …

[HTML][HTML] The Toxin of VapBC-1 Toxin-Antitoxin Module from Leptospira interrogans Is a Ribonuclease That Does Not Arrest Bacterial Growth but Affects Cell Viability

DK Damiano, BOP Azevedo, GSC Fernandes… - Microorganisms, 2024 - mdpi.com
Bacterial ubiquitous Toxin-Antitoxin (TA) systems are considered to be important survival
mechanisms during stress conditions. In regular environmental conditions, the antitoxin …

Unusual and Unconsidered Mechanisms of Bacterial Resilience and Resistance to Quinolones

J Ruiz - Life, 2024 - mdpi.com
Quinolone resistance has been largely related to the presence of specific point mutations in
chromosomal targets, with an accessory role of impaired uptake and enhanced pump-out …

Toxin-Antitoxin system of Mycobacterium tuberculosis: Roles beyond stress sensor and growth regulator

F Ahmad, MI Ansari, M Ashfaque, MH Islam, M Khubaib - Tuberculosis, 2023 - Elsevier
The advent of effective drug regimen and BCG vaccine has significantly decreased the rate
of morbidity and mortality of TB. However, lengthy treatment and slower recovery rate, as …

Unraveling the evolutionary dynamics of toxin-antitoxin systems in diverse genetic lineages of Escherichia coli including the high-risk clonal complexes

A Singh, AK Lankapalli, SK Mendem, T Semmler… - Mbio, 2024 - Am Soc Microbiol
Escherichia coli is a highly versatile microorganism with a unique ability to survive and
persist in varied niches of the human and animal hosts and the environment. While …