Carbonic anhydrase and bacterial metabolism: a chance for antibacterial drug discovery
C Capasso, CT Supuran - Expert Opinion on Therapeutic Patents, 2024 - Taylor & Francis
ABSTRACT Introduction Carbonic anhydrases (CAs, EC 4.2. 1.1) play a pivotal role in the
regulation of carbon dioxide, bicarbonate, and hydrogen ions within bacterial cells, ensuring …
regulation of carbon dioxide, bicarbonate, and hydrogen ions within bacterial cells, ensuring …
Type II bacterial toxin–antitoxins: hypotheses, facts, and the newfound plethora of the PezAT system
Toxin–antitoxin (TA) systems are entities found in the prokaryotic genomes, with eight
reported types. Type II, the best characterized, is comprised of two genes organized as an …
reported types. Type II, the best characterized, is comprised of two genes organized as an …
Decoding bacterial persistence: mechanisms and strategies for effective eradication
The ability of pathogenic bacteria to evade antibiotic treatment is an intricate and
multifaceted phenomenon. Over the years, treatment failure among patients due to …
multifaceted phenomenon. Over the years, treatment failure among patients due to …
Bacterial persister cells and development of antibiotic resistance in chronic infections: an update
AP Kunnath, M Suodha Suoodh… - British Journal of …, 2024 - frontierspartnerships.org
The global issue of antimicrobial resistance poses significant challenges to public health.
The World Health Organization (WHO) has highlighted it as a major global health threat …
The World Health Organization (WHO) has highlighted it as a major global health threat …
[HTML][HTML] Friends and foes: Bacteria of the hydroponic plant microbiome
Hydroponic greenhouses and vertical farms provide an alternative crop production strategy
in regions that experience low temperatures, suboptimal sunlight, or inadequate soil quality …
in regions that experience low temperatures, suboptimal sunlight, or inadequate soil quality …
Distribution patterns and influential factors of pathogenic bacteria in freshwater aquaculture sediments
W Xi, X Zhang, X Zhu, J Wang, H Xue, H Pan - Environmental Science and …, 2024 - Springer
Pathogenic bacteria, the major causative agents of aquaculture diseases, are a serious
impediment to the aquaculture industry. However, the bioinformatics of pathogenic bacteria …
impediment to the aquaculture industry. However, the bioinformatics of pathogenic bacteria …
[HTML][HTML] The Toxin of VapBC-1 Toxin-Antitoxin Module from Leptospira interrogans Is a Ribonuclease That Does Not Arrest Bacterial Growth but Affects Cell Viability
DK Damiano, BOP Azevedo, GSC Fernandes… - Microorganisms, 2024 - mdpi.com
Bacterial ubiquitous Toxin-Antitoxin (TA) systems are considered to be important survival
mechanisms during stress conditions. In regular environmental conditions, the antitoxin …
mechanisms during stress conditions. In regular environmental conditions, the antitoxin …
Unusual and Unconsidered Mechanisms of Bacterial Resilience and Resistance to Quinolones
J Ruiz - Life, 2024 - mdpi.com
Quinolone resistance has been largely related to the presence of specific point mutations in
chromosomal targets, with an accessory role of impaired uptake and enhanced pump-out …
chromosomal targets, with an accessory role of impaired uptake and enhanced pump-out …
Toxin-Antitoxin system of Mycobacterium tuberculosis: Roles beyond stress sensor and growth regulator
The advent of effective drug regimen and BCG vaccine has significantly decreased the rate
of morbidity and mortality of TB. However, lengthy treatment and slower recovery rate, as …
of morbidity and mortality of TB. However, lengthy treatment and slower recovery rate, as …
Unraveling the evolutionary dynamics of toxin-antitoxin systems in diverse genetic lineages of Escherichia coli including the high-risk clonal complexes
Escherichia coli is a highly versatile microorganism with a unique ability to survive and
persist in varied niches of the human and animal hosts and the environment. While …
persist in varied niches of the human and animal hosts and the environment. While …