Monocytes in the tumor microenvironment
S Ugel, S Canè, F De Sanctis… - Annual Review of …, 2021 - annualreviews.org
Immunotherapy has revolutionized cancer treatment over the past decade. Nonetheless,
prolonged survival is limited to relatively few patients. Cancers enforce a multifaceted …
prolonged survival is limited to relatively few patients. Cancers enforce a multifaceted …
How transcription factors drive choice of the T cell fate
H Hosokawa, EV Rothenberg - Nature Reviews Immunology, 2021 - nature.com
Recent evidence has elucidated how multipotent blood progenitors transform their identities
in the thymus and undergo commitment to become T cells. Together with environmental …
in the thymus and undergo commitment to become T cells. Together with environmental …
From haematopoietic stem cells to complex differentiation landscapes
E Laurenti, B Göttgens - Nature, 2018 - nature.com
The development of mature blood cells from haematopoietic stem cells has long served as a
model for stem-cell research, with the haematopoietic differentiation tree being widely used …
model for stem-cell research, with the haematopoietic differentiation tree being widely used …
[HTML][HTML] DNA methylation clocks in aging: categories, causes, and consequences
Age-associated changes to the mammalian DNA methylome are well documented and
thought to promote diseases of aging, such as cancer. Recent studies have identified …
thought to promote diseases of aging, such as cancer. Recent studies have identified …
Epigenetic control of CD8+ T cell differentiation
Upon stimulation, small numbers of naive CD8+ T cells proliferate and differentiate into a
variety of memory and effector cell types. CD8+ T cells can persist for years and kill tumour …
variety of memory and effector cell types. CD8+ T cells can persist for years and kill tumour …
[HTML][HTML] Integrative analysis of 111 reference human epigenomes
The reference human genome sequence set the stage for studies of genetic variation and its
association with human disease, but epigenomic studies lack a similar reference. To …
association with human disease, but epigenomic studies lack a similar reference. To …
DNA methylation disruption reshapes the hematopoietic differentiation landscape
Mutations in genes involved in DNA methylation (DNAme; for example, TET2 and DNMT3A)
are frequently observed in hematological malignancies,–and clonal hematopoiesis …
are frequently observed in hematological malignancies,–and clonal hematopoiesis …
[HTML][HTML] Replacement of lost Lgr5-positive stem cells through plasticity of their enterocyte-lineage daughters
Intestinal crypts display robust regeneration upon injury. The relatively rare secretory
precursors can replace lost stem cells, but it is unknown if the abundant enterocyte …
precursors can replace lost stem cells, but it is unknown if the abundant enterocyte …
[HTML][HTML] DNA methylation: an epigenetic mark of cellular memory
M Kim, J Costello - Experimental & molecular medicine, 2017 - nature.com
DNA methylation is a stable epigenetic mark that can be inherited through multiple cell
divisions. During development and cell differentiation, DNA methylation is dynamic, but …
divisions. During development and cell differentiation, DNA methylation is dynamic, but …
Lineage-specific and single-cell chromatin accessibility charts human hematopoiesis and leukemia evolution
We define the chromatin accessibility and transcriptional landscapes in 13 human primary
blood cell types that span the hematopoietic hierarchy. Exploiting the finding that the …
blood cell types that span the hematopoietic hierarchy. Exploiting the finding that the …