BACKGROUND Although the immune system intuitively must have an important role in
embryo implantation and in the achievement of a pregnancy, the molecular details have for …

Despite decades of research, the highly prevalent pregnancy complication
preeclampsia,“the disease of theories,” has remained an enigma. Indeed, the etiology of …

Fertility traits in humans are heritable, however, little is known about the genes that influence
reproductive outcomes or the genetic variants that contribute to differences in these traits …

Sertoli cells, can function as non-professional tolerogenic antigen-presenting cells and
sustain the blood-testis barrier formed by their tight junctions. The NOD-like receptor family …

Background/Aims: Pregnancy success requires mandatory maternal tolerance of the
semi/allogeneic embryo involving embryo-derived signals. Expression levels of …

The granted European patent EP 2 561 890 describes a procedure for an immunological
treatment of cancer. It is based on the principles of the HLA-supported communication of …

Maternal immunologic mechanisms for tolerance are essential for a successful pregnancy
because they prevent maladaptive immune responses to the placenta and semi-allogeneic …

The adaptor protein Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa
(SLP-76) plays a crucial role in T cell activation by linking antigen receptor (T cell receptor …

Problem The immune system plays an essential role in embryonic implantation and
pregnancy, but the molecular details remain controversial. In the past four decades, human …

Interactions between pairs of membrane-bound receptors can enhance tumour development
with implications for targeted therapies for cancer. Here we demonstrate clear heterotypic …