Abstract The Ca2+-sensing receptor (CaSR) is a dimeric family CG protein-coupled receptor
that is expressed in calcitropic tissues such as the parathyroid glands and the kidneys and …

The cloning of a G protein-coupled extracellular Ca2+ (Cao 2+)-sensing receptor (CaR) has
elucidated the molecular basis for many of the previously recognized effects of Cao 2+ on …

There is evidence from both observational studies and clinical trials that calcium malnutrition
and hypovitaminosis D are predisposing conditions for various common chronic diseases. In …

The discovery of a G protein–coupled, calcium-sensing receptor (CaR) a decade ago and of
diseases caused by CaR mutations provided unquestionable evidence of the CaR's critical …

The calcium-sensing receptor (CaSR) is a class CG protein–coupled receptor that responds
to multiple endogenous agonists and allosteric modulators, including divalent and trivalent …

A low vitamin D status and inadequate calcium intake are important risk factors for various
types of cancer. Ecological studies using solar UV-B exposure as an index of vitamin D3 …

Compelling evidence of a cell surface receptor sensitive to extracellular calcium was
observed as early as the 1980s and was finally realized in 1993 when the calcium-sensing …

Vitamin D and calcium are metabolically interrelated and highly correlated dietary factors.
Experimental studies have shown their anticarcinogenic effects due to their participation in …

The calcium sensing receptor (CaSR) is a class C G-protein-coupled receptor that is crucial
for the feedback regulation of extracellular free ionised calcium homeostasis. While …

Metastasis of breast cancer to bone occurs with advanced disease and produces substantial
morbidity. Secretion of PTH-related peptide (PTHrP) from breast cancer cells is thought to …