The concept of a scaffold concerns many aspects at different steps on the drug development
path. In medicinal chemistry, the choice of relevant “drug-likeness” scaffold is a starting point …

Natural compounds are rich in pharmacological properties that are a hot topic in
pharmaceutical research. The quinoline ring plays important roles in many biological …

A series of novel compounds carrying 1, 2, 4-triazole scaffold was synthesized and
evaluated for their anticancer activity against a panel of cancer cell lines using MTT assay …

A series of novel quinoline–chalcone derivatives were designed, synthesized, and
evaluated for their antiproliferative activity. Among them, compound 24d exhibited the most …

The combretastatins are isolated from South African tree combretum caffrum kuntze. The
lead compound combretastatin A-4 has displayed remarkable cytotoxic effect in a wide …

A series of chiral β-lactam bridged analogues (3-substituted 1, 4-diaryl-2-azetidinones) of
combretastatin A-4 (CA-4) were synthesized asymmetrically, and their antitumor activities …

Microtubules, formed by α-and β-tubulin heterodimer, are considered as a major target to
prevent the proliferation of tumor cells. Microtubule-targeted agents have become …

Here, we have synthesized a copper complex of plumbagin (Cu-PLN) and investigated its
antiproliferative activities in different cancer cells. The crystal structure of Cu-PLN showed …

The dynamic and crucial role of tubulin in different cellular functions rendered it a promising
target in anticancer drug development. Combretastatin A-4 (CA-4), an inhibitor of tubulin …

Combretastatin A-4 (CA-4) is a potent tubulin polymerisation inhibitor. However, the clinical
application of CA-4 is limited owing to its low aqueous solubility and the easy conversion of …