Tumor microenvironment (TME) is a specialized ecosystem of host components, designed
by tumor cells for successful development and metastasis of tumor. With the advent of 3D …

Cancer immunogenomics originally was framed by research supporting the hypothesis that
cancer mutations generated novel peptides seen as" non-self" by the immune system. The …

Studies have demonstrated that at least 20% of individuals infected with SARS-CoV-2
remain asymptomatic,,–. Although most global efforts have focused on severe illness in …

Multiple sclerosis (MS) is a heterogenous autoimmune disease in which autoreactive
lymphocytes attack the myelin sheath of the central nervous system. B lymphocytes in the …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus is causing a
global pandemic, and cases continue to rise. Most infected individuals experience mildly …

Most of what we know about adaptive immunity has come from inbred mouse studies, using
methods that are often difficult or impossible to confirm in humans. In addition, vaccine …

To gain mechanistic insights into the functions and developmental dynamics of tumor-
infiltrated immune cells, especially B-lymphocytes, here we combine single-cell RNA …

Periodontal disease is more common in individuals with rheumatoid arthritis (RA) who have
detectable anti-citrullinated protein antibodies (ACPAs), implicating oral mucosal …

Advances in high-throughput sequencing technologies now allow for large-scale
characterization of B cell immunoglobulin (Ig) repertoires. The high germline and somatic …

IMGT®, the international ImMunoGeneTics information system®(http://www. imgt. org) is the
global reference in immunogenetics and immunoinformatics. By its creation in 1989 by …