Evolving concepts in progressive supranuclear palsy and other 4-repeat tauopathies

M Stamelou, G Respondek, N Giagkou… - Nature Reviews …, 2021 - nature.com
Tauopathies are classified according to whether tau deposits predominantly contain tau
isoforms with three or four repeats of the microtubule-binding domain. Those in which four …

Clinical spectrum of tauopathies

N Olfati, A Shoeibi, I Litvan - Frontiers in Neurology, 2022 - frontiersin.org
Tauopathies are both clinical and pathological heterogeneous disorders characterized by
neuronal and/or glial accumulation of misfolded tau protein. It is now well understood that …

Tau PET imaging in progressive supranuclear palsy: a systematic review and meta-analysis

J Jin, D Su, J Zhang, X Li, T Feng - Journal of Neurology, 2023 - Springer
Objectives To evaluate the difference of tau burden between patients with progressive
supranuclear palsy (PSP) and healthy controls (HCs) or other neurodegenerative diseases …

Magnetic susceptibility in progressive supranuclear palsy variants, Parkinson's disease, and Corticobasal syndrome

R Satoh, SD Weigand, NTT Pham, F Ali… - Movement …, 2023 - Wiley Online Library
Background Previous studies have shown that magnetic susceptibility is increased in
several subcortical regions in progressive supranuclear palsy (PSP). However, it is still …

Brainstem biomarkers of clinical variant and pathology in progressive supranuclear palsy

RM Grijalva, NTT Pham, Q Huang… - Movement …, 2022 - Wiley Online Library
Background Magnetic resonance brainstem measurements are useful structural biomarkers
in the Richardson's syndrome variant of progressive supranuclear palsy (PSP). However, it …

Uncovering spatiotemporal patterns of atrophy in progressive supranuclear palsy using unsupervised machine learning

WJ Scotton, C Shand, E Todd, M Bocchetta… - Brain …, 2023 - academic.oup.com
To better understand the pathological and phenotypic heterogeneity of progressive
supranuclear palsy and the links between the two, we applied a novel unsupervised …

Differentiating between common PSP phenotypes using structural MRI: a machine learning study

A Quattrone, A Sarica, J Buonocore, M Morelli… - Journal of …, 2023 - Springer
Abstract Background Differentiating Progressive supranuclear palsy-Richardson's syndrome
(PSP-RS) from PSP-Parkinsonism (PSP-P) may be extremely challenging. In this study, we …

Differential diagnosis of rare subtypes of progressive supranuclear palsy and PSP-like syndromes—infrequent manifestations of the most common form of atypical …

P Krzosek, N Madetko, A Migda, B Migda… - Frontiers in Aging …, 2022 - frontiersin.org
Presently, there is increasing interest in rare PSP (progressive supranuclear palsy) variants,
including PSP-PGF (PSP-progressive gait freezing), PSP-PI (PSP-postural instability), PSP …

[HTML][HTML] Direct comparison between 18F-Flortaucipir tau PET and quantitative susceptibility mapping in progressive supranuclear palsy

R Satoh, F Ali, H Botha, VJ Lowe, KA Josephs… - Neuroimage, 2024 - Elsevier
Purpose The pattern of flortaucipir tau PET uptake is topographically similar to the pattern of
magnetic susceptibility in progressive supranuclear palsy (PSP); both with increased signal …

New perspectives in radiological and radiopharmaceutical hybrid imaging in progressive supranuclear palsy: a systematic review

J Strobel, HP Müller, AC Ludolph, AJ Beer, N Sollmann… - Cells, 2023 - mdpi.com
Progressive supranuclear palsy (PSP) is a neurodegenerative disease characterized by four-
repeat tau deposition in various cell types and anatomical regions, and can manifest as …