Individuals diagnosed with schizophrenia or bipolar disorder have a life expectancy 15–20
years shorter than that in the general population. The rate of unnatural deaths, such as …

Bipolar disorder (BD) is strongly associated with immune dysfunction. Replicated
epidemiological studies have demonstrated that BD has high rates of inflammatory medical …

Many psychiatric illnesses are associated with early mortality and with an increased risk of
developing physical diseases that are more typically seen in the elderly. Moreover, certain …

Objective: We reviewed important clinical aspects of bipolar depression, a progressive
psychiatric condition that is commonly treated in primary care. Bipolar depression is …

Objectives In the coming generation, older adults with bipolar disorder (BD) will increase in
absolute numbers as well as proportion of the general population. This is the first report of …

Objective Post-traumatic stress disorder (PTSD) has major public health significance.
Evidence that PTSD may be associated with premature senescence (early or accelerated …

Schizophrenia and bipolar disorder (BD) may be disorders of accelerated aging. Direct
comparison of healthy aging populations with schizophrenia and BD patients across the …

Objective Life expectancy in patients with bipolar disorder has been reported to be
decreased by 11 to 20 years. These calculations are based on data for individuals at the age …

Background Accelerated aging has been proposed as a mechanism explaining the
increased prevalence of comorbid general medical illnesses in bipolar disorder. Aims To …

Bipolar disorder (BD) is a chronic mental illness characterized by changes in mood that
alternate between mania and hypomania or between depression and mixed states, often …