Blood–brain barrier models and their relevance for a successful development of CNS drug delivery systems: a review
During the research and development of new drugs directed at the central nervous system,
there is a considerable attrition rate caused by their hampered access to the brain by the …
there is a considerable attrition rate caused by their hampered access to the brain by the …
Involvement of Astrocytes in the Formation, Maintenance, and Function of the Blood–Brain Barrier
G Schiera, CM Di Liegro, G Schirò, G Sorbello… - Cells, 2024 - mdpi.com
The blood–brain barrier (BBB) is a fundamental structure that protects the composition of the
brain by determining which ions, metabolites, and nutrients are allowed to enter the brain …
brain by determining which ions, metabolites, and nutrients are allowed to enter the brain …
Involvement of the pyrilamine transporter, a putative organic cation transporter, in blood-brain barrier transport of oxycodone
T Okura, A Hattori, Y Takano, T Sato… - Drug metabolism and …, 2008 - ASPET
The purpose of this study was to characterize blood-brain barrier (BBB) transport of
oxycodone, a cationic opioid agonist, via the pyrilamine transporter, a putative organic …
oxycodone, a cationic opioid agonist, via the pyrilamine transporter, a putative organic …
Design, synthesis and brain uptake of LAT1-targeted amino acid prodrugs of dopamine
L Peura, K Malmioja, K Huttunen, J Leppänen… - Pharmaceutical …, 2013 - Springer
Purpose Drug delivery to the brain is impeded by the blood-brain barrier (BBB). Here, we
attempted to enhance the brain uptake of cationic dopamine by utilizing the large amino acid …
attempted to enhance the brain uptake of cationic dopamine by utilizing the large amino acid …
Simultaneous determination of levodopa, carbidopa and tryptophan using nanostructured electrochemical sensor based on novel hydroquinone and carbon …
M Mazloum-Ardakani, B Ganjipour, H Beitollahi… - Electrochimica …, 2011 - Elsevier
In the present paper, the use of a novel carbon paste electrode modified by 2, 2′-[1, 2-
ethanediylbis (nitriloethylidyne)]-bis-hydroquinone (EBNBH) and carbon nanotubes …
ethanediylbis (nitriloethylidyne)]-bis-hydroquinone (EBNBH) and carbon nanotubes …
Pharmacokinetics, Pharmacodynamics and Tolerability of Opicapone, a Novel Catechol-O-Methyltransferase Inhibitor, in Healthy Subjects: Prediction of Slow …
Abstract Background and Objectives Opicapone is a novel catechol-O-methyltransferase
(COMT) inhibitor. The purpose of this study was to evaluate the tolerability …
(COMT) inhibitor. The purpose of this study was to evaluate the tolerability …
Effect of opicapone on levodopa pharmacokinetics, catechol‐O‐methyltransferase activity and motor fluctuations in patients with Parkinson's disease
JJ Ferreira, JF Rocha, A Falcão… - European Journal of …, 2015 - Wiley Online Library
Background and purpose Opicapone (OPC) is a novel third generation catechol‐O‐
methyltransferase (COMT) inhibitor that enhances levodopa availability. This study …
methyltransferase (COMT) inhibitor that enhances levodopa availability. This study …
Electrocatalytic oxidation and voltammetric determination of levodopa in the presence of carbidopa at the surface of a nanostructure based electrochemical sensor
In the present paper, the use of a carbon paste electrode modified by meso-tetrakis (3-
methylphenyl) cobalt porphyrin (CP) and TiO2 nanoparticles for the determination of …
methylphenyl) cobalt porphyrin (CP) and TiO2 nanoparticles for the determination of …
Opicapone: a short lived and very long acting novel catechol‐O‐methyltransferase inhibitor following multiple dose administration in healthy subjects
Aims The aim of this study was to assess the tolerability, pharmacokinetics and inhibitory
effect on erythrocyte soluble catechol‐O‐methyltransferase (S‐COMT) activity following …
effect on erythrocyte soluble catechol‐O‐methyltransferase (S‐COMT) activity following …
Effect of opicapone and entacapone upon levodopa pharmacokinetics during three daily levodopa administrations
Background and objectives Opicapone is a novel third generation catechol-O-
methyltransferase (COMT) inhibitor. The purpose of this study was to compare the levodopa …
methyltransferase (COMT) inhibitor. The purpose of this study was to compare the levodopa …