The code and beyond: transcription regulation by the RNA polymerase II carboxy-terminal domain
KM Harlen, LS Churchman - Nature reviews Molecular cell biology, 2017 - nature.com
The carboxy-terminal domain (CTD) extends from the largest subunit of RNA polymerase II
(Pol II) as a long, repetitive and largely unstructured polypeptide chain. Throughout the …
(Pol II) as a long, repetitive and largely unstructured polypeptide chain. Throughout the …
The RNA polymerase II CTD coordinates transcription and RNA processing
The C-terminal domain (CTD) of the RNA polymerase II largest subunit consists of multiple
heptad repeats (consensus Tyr1–Ser2–Pro3–Thr4–Ser5–Pro6–Ser7), varying in number …
heptad repeats (consensus Tyr1–Ser2–Pro3–Thr4–Ser5–Pro6–Ser7), varying in number …
The pol II CTD: new twists in the tail
J Zaborowska, S Egloff, S Murphy - Nature structural & molecular …, 2016 - nature.com
The C-terminal domain (CTD) of the large subunit of RNA polymerase (pol) II comprises
conserved heptad repeats, and post-translational modification of the CTD regulates …
conserved heptad repeats, and post-translational modification of the CTD regulates …
Dynamic phosphorylation patterns of RNA polymerase II CTD during transcription
M Heidemann, C Hintermair, K Voß, D Eick - Biochimica et Biophysica Acta …, 2013 - Elsevier
The eukaryotic RNA polymerase II (RNAPII) catalyzes the transcription of all protein
encoding genes and is also responsible for the generation of small regulatory RNAs. RNAPII …
encoding genes and is also responsible for the generation of small regulatory RNAs. RNAPII …
WWP2 is an E3 ubiquitin ligase for PTEN
PTEN, a lipid phosphatase, is one of the most frequently mutated tumour suppressors in
human cancer. Several recent studies have highlighted the importance of ubiquitylation in …
human cancer. Several recent studies have highlighted the importance of ubiquitylation in …
Osteoclasts have multiple roles in bone in addition to bone resorption
Osteoclasts are the cells that degrade bone to initiate normal bone remodeling and mediate
bone loss in pathologic conditions by increasing their resorptive activity. They are derived …
bone loss in pathologic conditions by increasing their resorptive activity. They are derived …
The RNA polymerase II CTD: the increasing complexity of a low-complexity protein domain
The largest subunit of RNA polymerase II contains a C-terminal domain (CTD) that plays key
roles in coordinating transcription with co-transcriptional events. The heptapeptide repeats …
roles in coordinating transcription with co-transcriptional events. The heptapeptide repeats …
Selective targeting of ubiquitination and degradation of PARP1 by E3 ubiquitin ligase WWP2 regulates isoproterenol-induced cardiac remodeling
N Zhang, Y Zhang, H Qian, S Wu, L Cao… - Cell Death & …, 2020 - nature.com
The elevated expression of poly (ADP-ribose) polymerase-1 (PARP1) and increased PARP1
activity, namely, poly (ADP-ribosyl) ation (PARylation), have been observed in cardiac …
activity, namely, poly (ADP-ribosyl) ation (PARylation), have been observed in cardiac …
WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks
P Caron, T Pankotai, WW Wiegant… - Genes & …, 2019 - genesdev.cshlp.org
DNA double-strand breaks (DSBs) at RNA polymerase II (RNAPII) transcribed genes lead to
inhibition of transcription. The DNA-dependent protein kinase (DNA-PK) complex plays a …
inhibition of transcription. The DNA-dependent protein kinase (DNA-PK) complex plays a …
The writers, readers, and functions of the RNA polymerase II C-terminal domain code
Transcription in the nucleus of animal cells is performed by three distinct RNA polymerases
(RNAP), namely RNAPI, RNAPII, and RNAPIII. Among them, RNAPII is responsible for the …
(RNAP), namely RNAPI, RNAPII, and RNAPIII. Among them, RNAPII is responsible for the …