Advances in menaquinone biosynthesis: sublocalisation and allosteric regulation
JM Johnston, EMM Bulloch - Current opinion in structural biology, 2020 - Elsevier
Highlights•Menaquinones (MKs) are involved in bacterial electron transport and
adaptation.•The Men pathway is the most predominant of two bacterial pathways to make …
adaptation.•The Men pathway is the most predominant of two bacterial pathways to make …
Quinones: more than electron shuttles
Bacterial quinones are lipophilic redox compounds involved in important cellular roles such
as electron transport in respiratory and photosynthetic chains. However, a growing body of …
as electron transport in respiratory and photosynthetic chains. However, a growing body of …
Predicting nitroimidazole antibiotic resistance mutations in Mycobacterium tuberculosis with protein engineering
Our inability to predict which mutations could result in antibiotic resistance has made it
difficult to rapidly identify the emergence of resistance, identify pre-existing resistant …
difficult to rapidly identify the emergence of resistance, identify pre-existing resistant …
Biological activity of amphiphilic metal complexes
C Schattschneider, SD Kettenmann, S Hinojosa… - Coordination Chemistry …, 2019 - Elsevier
Metal complexes with biological activity are of increasing importance in medicine as
potential alternatives for biologically active organic compounds, which often show severe …
potential alternatives for biologically active organic compounds, which often show severe …
Speciation and toxicity of rhenium salts, organometallics and coordination complexes
AA Haase, EB Bauer, FE Kühn, DC Crans - Coordination chemistry reviews, 2019 - Elsevier
Although rhenium (Re) is a rare element, it is an economically important one due to its use
as a catalyst in the chemical preparation of gasoline and in technologically vital alloys. While …
as a catalyst in the chemical preparation of gasoline and in technologically vital alloys. While …
Chemistry of lipoquinones: properties, synthesis, and membrane location of ubiquinones, plastoquinones, and menaquinones
MM Braasch-Turi, JT Koehn, DC Crans - International Journal of …, 2022 - mdpi.com
Lipoquinones are the topic of this review and are a class of hydrophobic lipid molecules with
key biological functions that are linked to their structure, properties, and location within a …
key biological functions that are linked to their structure, properties, and location within a …
Synthesis of naphthoquinone derivatives: menaquinones, lipoquinones and other vitamin K derivatives
M Braasch-Turi, DC Crans - Molecules, 2020 - mdpi.com
Menaquinones are a class of isoprenoid molecules that have important roles in human
biology and bacterial electron transport, and multiple methods have been developed for …
biology and bacterial electron transport, and multiple methods have been developed for …
Proline Dehydrogenase and Pyrroline 5 Carboxylate Dehydrogenase from Mycobacterium tuberculosis: Evidence for Substrate Channeling
S Kumar, S Sega, JK Lynn-Barbe, DL Harris, JT Koehn… - Pathogens, 2023 - mdpi.com
In Mycobacterium tuberculosis, proline dehydrogenase (PruB) and∆ 1-pyrroline-5-
carboxylate (P5C) dehydrogenase (PruA) are monofunctional enzymes that catalyze proline …
carboxylate (P5C) dehydrogenase (PruA) are monofunctional enzymes that catalyze proline …
SAR Analysis of Small Molecules Interfering with Energy-Metabolism in Mycobacterium tuberculosis
F Appetecchia, S Consalvi, C Scarpecci, M Biava… - Pharmaceuticals, 2020 - mdpi.com
Tuberculosis remains the world's top infectious killer: it caused a total of 1.5 million deaths
and 10 million people fell ill with TB in 2018. Thanks to TB diagnosis and treatment, mortality …
and 10 million people fell ill with TB in 2018. Thanks to TB diagnosis and treatment, mortality …
Demethylmenaquinone Methyl Transferase Is a Membrane Domain-Associated Protein Essential for Menaquinone Homeostasis in Mycobacterium smegmatis
The intracellular membrane domain (IMD) in mycobacteria is a spatially distinct region of the
plasma membrane with diverse functions. Previous comparative proteomic analysis of the …
plasma membrane with diverse functions. Previous comparative proteomic analysis of the …