Advances in menaquinone biosynthesis: sublocalisation and allosteric regulation

JM Johnston, EMM Bulloch - Current opinion in structural biology, 2020 - Elsevier
Highlights•Menaquinones (MKs) are involved in bacterial electron transport and
adaptation.•The Men pathway is the most predominant of two bacterial pathways to make …

Quinones: more than electron shuttles

T Franza, P Gaudu - Research in Microbiology, 2022 - Elsevier
Bacterial quinones are lipophilic redox compounds involved in important cellular roles such
as electron transport in respiratory and photosynthetic chains. However, a growing body of …

Predicting nitroimidazole antibiotic resistance mutations in Mycobacterium tuberculosis with protein engineering

BM Lee, LK Harold, DV Almeida, L Afriat-Jurnou… - PLoS …, 2020 - journals.plos.org
Our inability to predict which mutations could result in antibiotic resistance has made it
difficult to rapidly identify the emergence of resistance, identify pre-existing resistant …

Biological activity of amphiphilic metal complexes

C Schattschneider, SD Kettenmann, S Hinojosa… - Coordination Chemistry …, 2019 - Elsevier
Metal complexes with biological activity are of increasing importance in medicine as
potential alternatives for biologically active organic compounds, which often show severe …

Speciation and toxicity of rhenium salts, organometallics and coordination complexes

AA Haase, EB Bauer, FE Kühn, DC Crans - Coordination chemistry reviews, 2019 - Elsevier
Although rhenium (Re) is a rare element, it is an economically important one due to its use
as a catalyst in the chemical preparation of gasoline and in technologically vital alloys. While …

Chemistry of lipoquinones: properties, synthesis, and membrane location of ubiquinones, plastoquinones, and menaquinones

MM Braasch-Turi, JT Koehn, DC Crans - International Journal of …, 2022 - mdpi.com
Lipoquinones are the topic of this review and are a class of hydrophobic lipid molecules with
key biological functions that are linked to their structure, properties, and location within a …

Synthesis of naphthoquinone derivatives: menaquinones, lipoquinones and other vitamin K derivatives

M Braasch-Turi, DC Crans - Molecules, 2020 - mdpi.com
Menaquinones are a class of isoprenoid molecules that have important roles in human
biology and bacterial electron transport, and multiple methods have been developed for …

Proline Dehydrogenase and Pyrroline 5 Carboxylate Dehydrogenase from Mycobacterium tuberculosis: Evidence for Substrate Channeling

S Kumar, S Sega, JK Lynn-Barbe, DL Harris, JT Koehn… - Pathogens, 2023 - mdpi.com
In Mycobacterium tuberculosis, proline dehydrogenase (PruB) and∆ 1-pyrroline-5-
carboxylate (P5C) dehydrogenase (PruA) are monofunctional enzymes that catalyze proline …

SAR Analysis of Small Molecules Interfering with Energy-Metabolism in Mycobacterium tuberculosis

F Appetecchia, S Consalvi, C Scarpecci, M Biava… - Pharmaceuticals, 2020 - mdpi.com
Tuberculosis remains the world's top infectious killer: it caused a total of 1.5 million deaths
and 10 million people fell ill with TB in 2018. Thanks to TB diagnosis and treatment, mortality …

Demethylmenaquinone Methyl Transferase Is a Membrane Domain-Associated Protein Essential for Menaquinone Homeostasis in Mycobacterium smegmatis

J Puffal, JA Mayfield, DB Moody, YS Morita - Frontiers in microbiology, 2018 - frontiersin.org
The intracellular membrane domain (IMD) in mycobacteria is a spatially distinct region of the
plasma membrane with diverse functions. Previous comparative proteomic analysis of the …