Injury to or disease of the nervous system can invoke chronic and sometimes intractable
neuropathic pain. Many parallel, interdependent, and time-dependent processes, including …

Somatostatin-expressing GABAergic neurons constitute a major class of inhibitory neurons
in the mammalian cortex and are characterized by dense wiring into the local network and …

The deep dorsal horn is a poorly characterized spinal cord region implicated in processing
low-threshold mechanoreceptor (LTMR) information. We report an array of mouse genetic …

The original formulation of Gate Control Theory (GCT) proposed that the perception of pain
produced by spinal cord signaling to the brain depends on a balance of activity generated in …

Neurons in the spinal dorsal horn process sensory information, which is then transmitted to
several brain regions, including those responsible for pain perception. The dorsal horn …

Stimuli that elicit itch are detected by sensory neurons that innervate the skin. This
information is processed by the spinal cord; however, the way in which this occurs is still …

The spinal dorsal horn receives input from primary afferent axons, which terminate in a
modality-specific fashion in different laminae. The incoming somatosensory information is …

The two amino acids GABA and glycine mediate fast inhibitory neurotransmission in different
CNS areas and serve pivotal roles in the spinal sensory processing. Under healthy …

Pain information processing in the spinal cord has been postulated to rely on nociceptive
transmission (T) neurons receiving inputs from nociceptors and Aβ mechanoreceptors, with …

Menthol and other counterstimuli relieve itch, resulting in an antipruritic state that persists for
minutes to hours. However, the neural basis for this effect is unclear, and the underlying …