[PDF][PDF] The role of dexmedetomidine in immune tissue and inflammatory diseases: a narrative review.

R Chen, XK Dou, MS Dai, Y Sun… - European Review for …, 2022 - europeanreview.org
OBJECTIVE: Adrenergic receptors belong to the G protein-coupled receptor family and are
one of the important targets of modern drug therapy. Dexmedetomidine (DEX) is a highly …

Integrating mechanistic-based and classification-based concepts into perioperative pain management: an educational guide for acute pain physicians

Y Chen, E Wang, BD Sites, SP Cohen - Regional Anesthesia & Pain …, 2024 - rapm.bmj.com
Chronic pain begins with acute pain. Physicians tend to classify pain by duration (acute vs
chronic) and mechanism (nociceptive, neuropathic and nociplastic). Although this taxonomy …

[HTML][HTML] Bone marrow mesenchymal stem cell exosome-derived lncRNA TUC339 influences the progression of osteoarthritis by regulating synovial macrophage …

X Shen, J Qin, Z Wei, F Liu - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Osteoarthritis (OA) is an extremely common type of chronic progressive disease in clinical
practice. lncRNA TUC339 has a close association with bone marrow mesenchymal stem cell …

METTL14 promotes chondrocyte ferroptosis in osteoarthritis via m6A modification of GPX4

D Liu, L Ren, J Liu - International Journal of Rheumatic …, 2024 - Wiley Online Library
Background Ferroptosis is caused by iron‐dependent peroxidation of membrane
phospholipids and chondrocyte ferroptosis contributes to osteoarthritis (OA) progression …

Dexmedetomidine alleviates osteoarthritis inflammation and pain through the CB2 pathway in rats

X Li, C Zhang, H Tao, X Yang, X Qian, J Zhou… - International …, 2023 - Elsevier
As a common joint disease, osteoarthritis (OA) is often associated with chronic pain.
Synovial inflammation is correlated with OA progression and pain. Synovial inflammation …

[HTML][HTML] Evaluating the effects of rifampin in the prevention of neurogenic symptoms and cardiac arrhythmias caused by the systemic toxicity of lidocaine in rats

S Kazemi-Darabadi, S Tavakoli, Y Panahi… - Veterinary Research …, 2023 - ncbi.nlm.nih.gov
Lidocaine toxicity is caused by unintended intravascular injection or overdose. Lidocaine is
metabolized in the liver by the CYP3A4 isoenzyme. The objective was to investigate if the …

人参多糖干预创伤性骨关节炎模型大鼠前列腺素E2/6-酮-前列腺素F1α 的表达

李蕊, 张桂红, 王涛, 樊萍 - 中国组织工程研究, 2024 - cjter.com
人参多糖干预创伤性骨关节炎模型大鼠前列腺素E2/6- 酮- 前列腺素F 的表达 Page 1 Chinese
Journal of Tissue Engineering Research|Vol 28|No.8|March 2024|1235 中国组织工程研究 …

Intra-articular dexmedetomidine improves outcomes of postoperative analgesia after arthroscopic meniscus surgery

EMSM Elafifi, MM Abouseeda… - Egyptian Journal of …, 2024 - Taylor & Francis
Objectives The evaluation of the outcomes of patients undergoing arthroscopic unilateral
meniscus repair on receiving intra-articular injection (IAI) of dexmedetomidine (DXM) alone …

Dexmedetomidine Effectively Sedates Asian Elephants (Elephas maximus)

N Buranapim, P Kulnanan, K Chingpathomkul… - Animals, 2022 - mdpi.com
Simple Summary Sedation in standing procedures is commonly performed in elephants. To
successfully and safely initiate standing in elephants, chemical restraint drugs should …

Concentrations of dexmedetomidine and effect on biomarkers of cartilage toxicity following intra-articular administration in horses

HK Knych, K Mama, M Oakleaf… - American Journal of …, 2023 - Am Vet Med Assoc
OBJECTIVE The goal of this study was to determine plasma, urine, and synovial fluid
concentrations and describe the effects on biomarkers of cartilage toxicity following intra …