Piperazine ranks as the third most common N-heterocycle appearing in small-molecule
pharmaceuticals. This review highlights recent advances in methods development for the …

The inherent reactivity of the aziridine ring due to ring-strain makes it valuable building
blocks for the synthesis of other heterocyclic motifs of biological relevance. Of particular …

The catalytic potential of a large series of easily available metal carbamates (based on
thirteen different non-precious metal elements) was explored for the first time in the coupling …

A highly selective Lewis acid catalyzed annulation of three-membered heterocycles with
nitrones has been developed. Oxiranes, aziridines, and thiiranes were used as substrates …

The catalytic potential of ammonium halide salts was explored in the coupling reaction of a
model aziridine with carbon dioxide, highlighting the superior activity of [NH2Et2] I. Then …

Flow chemistry: A flow‐microreactor‐mediated synthesis of 1, 2, 3, 4‐
tetrahydroisoquinolines (THIQs) is reported (see scheme). Starting from a laterally lithiated …

Piperazine is one of the most frequently found scaffolds in small-molecule FDA-approved
drugs. In this study, a general approach to the synthesis of piperazines bearing substituents …

One-pot heterocyclic synthesis is an exciting research area as it can open routes for the
development of otherwise complex transformations in organic synthesis. Heterocyclic …

Piperazine is two nitrogen containing heterocyclic compound. The fundamental activity of
the piperazine is due to the 1, 4-position of nitrogen atoms and their substitutions. The SN 1 …

disubstituted N, N'‐alkylpiperazines represent an interesting target in organic synthesis both
for pharmaceutical or agrochemical applications and as a promising class of ligands in …