Biomineralization process in hard tissues: The interaction complexity within protein and inorganic counterparts
Biomineralization can be considered as nature's strategy to produce and sustain
biominerals, primarily via creation of hard tissues for protection and support. This review …
biominerals, primarily via creation of hard tissues for protection and support. This review …
The CAM model—Q&A with experts
D Fischer, G Fluegen, P Garcia… - Cancers, 2022 - mdpi.com
Simple Summary The chorioallantoic membrane (CAM) model is an alternative in vivo test
system for the study of hallmarks of cancer such as angiogenesis, tumor growth, immune …
system for the study of hallmarks of cancer such as angiogenesis, tumor growth, immune …
Endometrial Axin2+ cells drive epithelial homeostasis, regeneration, and cancer following oncogenic transformation
The remarkable regenerative capacity of the endometrium (the inner lining of the uterus) is
essential for the sustenance of mammalian life. Over the years, the role of stem cells in …
essential for the sustenance of mammalian life. Over the years, the role of stem cells in …
[HTML][HTML] Applications of the chick chorioallantoic membrane as an alternative model for cancer studies
A variety of in vivo experimental models have been established for the studies of human
cancer using both cancer cell lines and patient-derived xenografts (PDXs). In order to meet …
cancer using both cancer cell lines and patient-derived xenografts (PDXs). In order to meet …
Multi-omics integration analysis robustly predicts high-grade patient survival and identifies CPT1B effect on fatty acid metabolism in bladder cancer
Purpose: The perturbation of metabolic pathways in high-grade bladder cancer has not
been investigated. We aimed to identify a metabolic signature in high-grade bladder cancer …
been investigated. We aimed to identify a metabolic signature in high-grade bladder cancer …
HRAS‐driven cancer cells are vulnerable to TRPML1 inhibition
J Jung, KJ Cho, AK Naji, KN Clemons, CO Wong… - EMBO …, 2019 - embopress.org
By serving as intermediaries between cellular metabolism and the bioenergetic demands of
proliferation, endolysosomes allow cancer cells to thrive under normally detrimental …
proliferation, endolysosomes allow cancer cells to thrive under normally detrimental …
Sulforaphane exerts anti-angiogenesis effects against hepatocellular carcinoma through inhibition of STAT3/HIF-1α/VEGF signalling
P Liu, SJ Atkinson, SE Akbareian, Z Zhou… - Scientific reports, 2017 - nature.com
Angiogenesis plays an important role in hepatocellular carcinoma (HCC), the inhibition of
which is explored for cancer prevention and treatment. The dietary phytochemical …
which is explored for cancer prevention and treatment. The dietary phytochemical …
Requirements for animal experiments: problems and challenges
In vivo models remain a principle screening tool in the drug discovery pipeline. Here, the
challenges associated with the need for animal experiments, as well as their impact on …
challenges associated with the need for animal experiments, as well as their impact on …
Cellular mechanisms of biodegradable zinc and magnesium materials on promoting angiogenesis
Biodegradable metals, zinc and magnesium, have been regarded as next-generation,
biomedical implant materials to promote tissue repair and regeneration. These implants …
biomedical implant materials to promote tissue repair and regeneration. These implants …
Development of bioluminescent chick chorioallantoic membrane (CAM) models for primary pancreatic cancer cells: a platform for drug testing
The aim of the present study was to develop chick-embryo chorioallantoic membrane (CAM)
bioluminescent tumor models employing low passage cell cultures obtained from primary …
bioluminescent tumor models employing low passage cell cultures obtained from primary …